3004-73-7Relevant academic research and scientific papers
Synthesis and antibacterial activities of pleuromutilin derivatives containing aryl urea groups
Zhang, Yuanyuan,Yang, Weiqing,Xu, Keping,Ma, Menglin,Wang, Yuliang
, p. 219 - 225 (2013/05/22)
A series of novel pleuromutilin derivatives containing aryl urea groups was synthesized and their antibacterial activities were evaluated in vitro against S. aureus ATCC 26113, S.aureus SC, S. albus ATCC 8799 and P. aeruginosa ATCC 27853. Most of compound
Formation of N-Substituted Trichloroacetamides from Amines and Hexachloroacetone
Bew, Clive,Joshi, Virginia Otero de,Gray, Jim,Kaye, Perry T.,Meakins, G. Denis
, p. 945 - 948 (2007/10/02)
Procedures are described for converting primary amines into their well-crystalline trichloroacetyl-derivatives by treatment with hexachloroacetone under mild conditions.Although secondary aromatic N-methylamines are unaffected by hexachloroacetone, saturated heterocyclic amines react vigorously.A mechanistic study using 2-amino-4-t-butylthiazole showed that the reaction is first order in hexachloroacetone, second order in amine, and base-catalysed; there is no appreciable kinetic isotope (H/D) effect nor accumulation of intermediates during the reaction.A sequence which accommodates these results is suggested.
