300402-61-3Relevant academic research and scientific papers
Rapidly Activating Pd-Precatalyst for Suzuki-Miyaura and Buchwald-Hartwig Couplings of Aryl Esters
Dardir, Amira H.,Melvin, Patrick R.,Davis, Ryan. M.,Hazari, Nilay,Mohadjer Beromi, Megan
, p. 469 - 477 (2018)
Esters are valuable electrophiles for cross-coupling due to their ubiquity and ease of synthesis. However, harsh conditions are traditionally required for the effective cross-coupling of ester substrates. Utilizing a recently discovered precatalyst, Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig reactions involving cleavage of the C(acyl)-O bond of aryl esters that proceed under mild conditions are reported. The Pd(II) precatalyst is highly active because it is reduced to the Pd(0) active species more rapidly than previous precatalysts.
Quantitative investigation of C-H?π and other intermolecular interactions in a series of crystalline: N -(substituted phenyl)-2-naphthamide derivatives
Shukla, Rahul,Saeed, Aamer,Simpson, Jim,Chopra, Deepak
, p. 5473 - 5491 (2017/09/26)
In this study, we have investigated the nature and characteristics of different intermolecular interactions present in a series of seven N-(substituted phenyl)-2-naphthamides. The seven structures comprise 2-naphthyl ring systems linked by amide bridges to N-bound phenyl 1, or substituted benzene rings 3-7, or in the case of 2, a cyclohexane ring. A common feature of the crystal packing for all but the o-nitro derivative 7 is the presence of a strong intermolecular N-H?O interaction. In the case of 7, the possibility of such an interaction is obviated by the formation of an intramolecular N-H?O hydrogen bond. An additional feature of the crystal packing for 1-6 is the significant roles that C-H?π contacts play in generating three-dimensional networks. In contrast for 7, the intramolecular N-H?O hydrogen bond precludes the formation of molecular chains but the planar nature of this molecule allows significant π?π stacking interactions to stabilize the packing.
One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines
?trukil, Vjekoslav,Bartolec, Boris,Portada, Tomislav,Dilovi?, Ivica,Halasz, Ivan,Margeti?, Davor
supporting information, p. 12100 - 12102 (2013/01/16)
Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.
