300402-71-5Relevant academic research and scientific papers
Hypervalent iodine mediated para -selective fluorination of anilides
Tian, Tian,Zhong, Wen-He,Meng, Shuai,Meng, Xiang-Bao,Li, Zhong-Jun
, p. 728 - 732 (2013/02/25)
A metal-free method for the direct regioselective fluorination of anilides has been developed. In the presence of bis(tert-butylcarbonyloxy)iodobenzene (PhI(OPiv)2) and hydrogen fluoride-pyridine, the para-fluorination products of anilides were obtained in moderate to good yields. Because of its operational safety and the use of readily available reagents, this new procedure provides facile access to a variety of para-fluorinated anilides.
One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines
?trukil, Vjekoslav,Bartolec, Boris,Portada, Tomislav,Dilovi?, Ivica,Halasz, Ivan,Margeti?, Davor
supporting information, p. 12100 - 12102 (2013/01/16)
Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.
Investigating the spectrum of biological activity of substituted quinoline-2-carboxamides and their isosteres
Gonec, Tomas,Bobal, Pavel,Sujan, Josef,Pesko, Matus,Guo, Jiahui,Kralova, Katarina,Pavlacka, Lenka,Vesely, Libor,Kreckova, Eva,Kos, Jiri,Coffey, Aidan,Kollar, Peter,Imramovsky, Ales,Placek, Lukas,Jampilek, Josef
, p. 613 - 644 (2012/03/09)
In this study, a series of thirty-five substituted quinoline-2-carboxamides and thirty-three substituted naphthalene-2-carboxamides were prepared and characterized. They were tested for their activity related to the inhibition of photosynthetic electron t
Amide-based inhibitors of p38α MAP kinase. Part 1: Discovery of novel N-pyridyl amide lead molecules
Luedtke, Gregory R.,Schinzel, Kurt,Tan, Xuefei,Tester, Richland W.,Nashashibi, Imad,Xu, Yong-jin,Dugar, Sundeep,Levy, Daniel E.,Jung, Joon
scheme or table, p. 2556 - 2559 (2010/07/03)
A novel series of N-pyridyl amides as potent p38α kinase inhibitors is described. Based on the structural similarities between the initial hit and a well-known imidazole pyrimidine series of p38α inhibitors, potencies within the newly discovered series were quickly improved by installation of an (S)-α-methylbenzyl moiety at the 2-position of the pyridine ring. The proposed binding modes of the new series to p38α were evaluated against SAR findings and provided rationale for further development of this series of molecules.
