30049-07-1

Usage

1-Ethyl-2-(trifluoromethyl)-1H-1,3-benzimidazole (Fomepizole)

2. Potent and selective inhibitor of alcohol dehydrogenase
3. Used as an antidote for methanol and ethylene glycol poisoning

Mechanism of action

Blocks the metabolism of toxic substances
5. Prevents the formation of harmful byproducts
6. Important pharmaceutical compound
7. Potentially life-saving effects in cases of accidental or deliberate ingestion of toxic alcohols

Upstream product

• 75-03-6 ethyl iodide 
• 312-73-2 2-Trifluoromethylbenzimidazole 

Relevant academic research and scientific papers

Key intermediate for synthesizing 1-alkyl-2-trifluoromethyl-5-amino-1H-imidazole, and preparation method thereof

The invention discloses a key intermediate for synthesizing 1-alkyl-2-trifluoromethyl-5-amino-1H-imidazole, and a preparation method thereof. A purpose of the invention is mainly to solve the technical problem of lack of a 1-alkyl-2-trifluoromethyl-5-amino-1H-imidazole synthesis process in the prior art. The method comprises the following steps: carrying out alkylation on a compound II (2-trifluoromethylbenzimidazole) as a raw material to generate a compound III; opening a benzene ring through oxidizing to obtain a diacid compound IV; esterifying the compound IV to generate a compound V; carrying out monohydrolysis to obtain a compound VI; carrying out cutius rearrangement on the compound VI to generate a compound VII; hydrolyzing the ester group of the compound VII to generate a compoundVIII; and finally carrying out decarboxylation and tert-butyloxycarbonyl removal to obtain the compound I (1-alkyl-2-trifluoromethyl-5-amino-1H-imidazole).

Organostannyl mediated synthesis of 1-alkyl- and 1-sulfonyl-2-trifluoromethylbenzimidazole derivatives

The synthesis and characteristics of a new series of 1-alkyl and 1-sulfonyl derivatives of 2-trifluoromethylbenzimidazole through an organostannyl intermediate is described.