30062-34-1

Basic information

• Product Name: Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate
• Synonyms: Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate;6-Methoxycarbonyl-2-pyridone;methyl 6-hydroxypicolinate
• CAS NO: 30062-34-1
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.13538
• Mol File: 30062-34-1.mol
• Article Data: 25

Chemical Properties

• Melting Point: 109-110 °C
• Boiling Point: 356.6°C at 760 mmHg
• Flash Point: 169.5°C
• Appearance: /
• Density: 1.287g/cm³
• Vapor Pressure: 1.41E-05mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.83±0.10(Predicted)
• CAS DataBase Reference: Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate(30062-34-1)
• EPA Substance Registry System: Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate(30062-34-1)

Safety Data

• Hazardous Substances Data: 30062-34-1(Hazardous Substances Data)

Usage

General Description

Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate is a chemical compound with the molecular formula C8H9NO3. It is commonly used in the synthesis of pharmaceuticals and agrochemicals. Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate is a dihydropyridine derivative, which has potential biological activities such as antioxidant, anti-inflammatory, and calcium channel blocking properties. It is also used as a building block in organic chemistry reactions, particularly in the production of calcium channel blockers, which are commonly used to treat hypertension and heart disease. Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate is an important intermediate in the pharmaceutical and agricultural industries due to its versatile reactivity and potential therapeutic benefits.

InChI:InChI=1/C7H7NO3/c1-11-7(10)5-3-2-4-6(9)8-5/h2-4H,1H3,(H,8,9)

Upstream product

• 19621-92-2 6-Hydroxypicolinic acid 
• 1006364-82-4 methyl 1-(benzyloxy)-6-oxo-1,2,3,6-tetrahydropyridine-2-carboxylate 
• 67-56-1 methanol 
• 19621-92-2 2-oxo-1,2-dihydropyridine-6-carboxylic acid 
• 38195-81-2 1-oxy-pyridine-2-carboxylic acid methyl ester 

Downstream Products

• 20845-22-1 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid methyl ester 
• 1131007-43-6 6-(difluoromethoxy)pyridin-2-amine 
• 90151-09-0 6-hydroxy-N-methylpicolinamide 
• 1375098-10-4 methyl 6-(difluoromethoxy)picolinate 
• 1420476-83-0 2-benzyl-7-bromo-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione 
• 1420476-93-2 2-benzyl-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione 

Relevant articles and documents

Synthesis, opto-physics, and electroluminescence of cyclometalated iridium (III) complex with alkyltrifluorene picolinic acid

To improve the opto-physics, electroluminescence, and dispersibility of iridium (III) complexes in polymer light-emitting devices, we synthesized and characterized two red-emitting heteroleptic cyclometalated iridium (III) complexes of (Piq)2Ir(Tfl-pic) and (Piq)2Ir(Brfl-pic), in which Piq is 1-phenylisoquinoline, Tfl-pic and Brfl-pic are alkyltrifluorene- and dibromoalkylfluorene-containing picolinic acid derivatives bridged with alkoxy chain, respectively. Compared to (Piq)2Ir(pic) and (Piq)2Ir(Brfl-pic), (Piq)2Ir(Tfl-pic) exhibited higher thermal stability, better dispersibility and excellent quantum efficiency. High-efficiency red emission with a maximum current efficiency of 6.28 cdA-1 and a maximum EL peak at 608 nm was obtained in the (Piq)2Ir(Tfl-pic)-doped devices using a blend of poly(9,9-dioctylfluorene) and 2-(4-biphenyl)-5-(4-tert -butylphenyl)-1,3,4-oxadiazole as a host matrix.

A multi-functional picolinohydrazide-based chemosensor for colorimetric detection of iron and dual responsive detection of hypochlorite

A novel effective chemosensor HPHN, (E)-6-hydroxy-N′-((2-hydroxynaphthalen-1-yl)methylene) picolinohydrazide, was synthesized. HPHN sensed Fe3+/2+ with the changes of color from yellow to orange without obvious inhibition from other cations. In addition, HPHN could detect ClO? by both the color change from yellow to colorless and the fluorescence quenching. The binding modes of HPHN with Fe3+/2+ and ClO? were determined to be 1:1 with Job plot and ESI-mass analysis. HPHN displayed low detection limits of 0.29 μM for Fe3+ and 0.77 μM for Fe2+. For ClO?, the detection limit was 6.20 μM by colorimetric method and 3.99 μM by fluorescent one, respectively. Moreover, HPHN can be employed to quantify Fe3+ and ClO? in environmental samples and apply to cell imaging for ClO?.

KIF18A INHIBITORS

Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.