30062-47-6

Basic information

• Product Name: 5-(Isopropylthio)-1,3,4-thiadiazol-2-amine
• Synonyms: 5-(Isopropylthio)-1,3,4-thiadiazol-2-amine;5-(isopropylthio)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE);5-(Isopropylsulfanyl)-1,3,4-thiadiazol-2-aMine
• CAS NO: 30062-47-6
• Molecular Formula: C₅H₉N₃S₂
• Molecular Weight: 175.28
• Mol File: 30062-47-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 147-150 °C
• Boiling Point: 320.8°C at 760 mmHg
• Flash Point: 147.8°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 0.00031mmHg at 25°C
• Refractive Index: 1.607
• PKA: 3.01±0.10(Predicted)
• CAS DataBase Reference: 5-(Isopropylthio)-1,3,4-thiadiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Isopropylthio)-1,3,4-thiadiazol-2-amine(30062-47-6)
• EPA Substance Registry System: 5-(Isopropylthio)-1,3,4-thiadiazol-2-amine(30062-47-6)

Safety Data

• Hazardous Substances Data: 30062-47-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H9N3S2/c1-3(2)9-5-8-7-4(6)10-5/h3H,1-2H3,(H2,6,7)

Upstream product

• 75-29-6 isopropyl chloride 
• 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole 
• 75-30-9 2-iodo-propane 
• 75-26-3 isopropyl bromide 

Downstream Products

• 1309650-86-9 4-(4-chlorobenzoyl)-5-(4-chlorophenyl)-3-hydroxy-1-(5-(isopropylthio)-1,3,4-thiadiazol-2-yl)-1H-pyrrol-2(5H)-one 

Relevant articles and documents

COMPOUNDS HAVING PDE9A INHIBITORY ACTIVITY, AND PHARMACEUTICAL USES THEREOF

The present invention provides a compound having a specific chemical structure and having PDE9A inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention provides a composition containing the compound or a pharmaceutically acceptable salt thereof. The present invention provides a pharmaceutical use, for treating or preventing PDE9A-related diseases, of the compound according to the present invention, a salt thereof, and a composition containing the compound or salt. The present invention also provides a method for treating or preventing PDE9A-related diseases, the method comprising administering an effective amount of the compound according to the present invention, a salt thereof, or a composition containing the compound or salt to a subject in need of treatment.

Synthesis and in vitro antitumor activity of 1,3,4-thiadiazole derivatives based on benzisoselenazolone

A series of novel 1,3,4-thiadiazole derivatives based on benzisoselenazolone were synthesized and evaluated for their cytotoxicity in vitro against human liver cancer cell SSMC-7721, human breast cancer cell MCF-7 and human lung cancer cell A549 by CCK-8 assay. The results showed that compounds 7e, 7f, 7h, 7k, 7l and 7m displayed good cytotoxicity against MCF-7 cell lines. Compound 7l exhibited the most potent antitumor activities among the tested compounds.

Thiadiazole derivatives for the treatment of depressive states

Thiadiazole derivatives of general formula (I) wherein R1 is selected from the class consisting of: C1-C10 linear or branched alkyl, benzyl, optionally substituted at the aromatic ring with one or more groups se