300663-06-3

Basic information

• Product Name: 5-(4-butyl-phenyl)-pent-4-ynoic acid ethyl ester
• CAS NO: 300663-06-3
• Molecular Weight: 258.36
• Mol File: 300663-06-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-butyl-phenyl)-pent-4-ynoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-butyl-phenyl)-pent-4-ynoic acid ethyl ester(300663-06-3)
• EPA Substance Registry System: 5-(4-butyl-phenyl)-pent-4-ynoic acid ethyl ester(300663-06-3)

Safety Data

• Hazardous Substances Data: 300663-06-3(Hazardous Substances Data)

Upstream product

• 6089-09-4 4-pentynoic acid 
• 63093-41-4 ethyl 4-pentynoate 
• 41492-05-1 p-bromobutylbenzene 

Downstream Products

• 300663-13-2 5-(4-butyl-phenyl)-pent-4-ynoyl chloride 
• 300663-10-9 5-(4-butyl-phenyl)-pent-4-ynoic acid 

Relevant articles and documents

Synthesis of 3-arylpropenyl, 3-arylpropynyl and 3-arylpropyl 2-azetidinones as cholesterol absorption inhibitors: Application of the palladium-catalyzed arylation of alkenes and alkynes

A series of 3-(3'-arylpropenyl)-2-azetidinones 8a-8k and 3-(3'-arylpropynyl)-2-azetidinones 16m-16p were prepared by the palladium-catalyzed arylation of 3-(3'-propenyl)-2-azetidinone 7, or by arylation of 4-pentenoic acid, or via ethyl 4-pentynoate followed by 2-azetidinone ring construction. The unsaturated 2-azetidinones were transformed to their saturated analogs 9a-9p by catalytic hydrogenation. Azetidinones 8a-8k, 9a-9p, and 16m-16p were evaluated for their biological activity as cholesterol absorption inhibitors in hamsters. (C) 2000 Elsevier Science Ltd.