300766-84-1

Basic information

• Product Name: methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate
• Synonyms: methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate
• CAS NO: 300766-84-1
• Molecular Weight: 539.629
• Mol File: 300766-84-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate(300766-84-1)
• EPA Substance Registry System: methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate(300766-84-1)

Safety Data

• Hazardous Substances Data: 300766-84-1(Hazardous Substances Data)

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 168766-64-1 methyl (S)-N'-(2,4-dimethoxybenzyl)tryptophanate 
• 4299-70-1 L-tryptophan methyl ester 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Downstream Products

• 300766-79-4 (3S,6S)-1-(o-azidobenzoyl)-4-(2'',4''-dimethoxybenzyl)-3-(3'-indolylmethyl)-6-methyl-2,5-piperazinedione 
• 300766-81-8 (1S,4S)-2-(2'',4''-dimethoxybenzyl)-1-(3'-indolylmethyl)-4-methyl-2,3,4,6-tetrahydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione 
• 204770-73-0 (4S)-2-(2'',4''-dimethoxybenzyl)-4-methyl-2,3,4,6-tetrahydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione 
• 17079-37-7 (3S,6S)-3-(3'-indolylmethyl)-6-methylpiperazine-2,5-dione 
• 300766-86-3 (3S,6S)-6-(3'-indolylmethyl)-3-methyl-1-(2,4-dimethoxybenzyl)-2,5-piperazinedione 

Relevant articles and documents

Synthesis of a seco analogue of ardeemin

(1S,4S)-1-Indolylmethyl-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]-q uinazaline-3,6-dione, a seco analogue of ardeemin, was synthesized in six steps from L-tryptophan methyl ester via an N-protected 2,5-piperazinedione and using an aza-Wittig reaction for the preparation of the quinazoline system. The final acid-promoted deprotection required tuning of the reaction conditions in order to minimize a side reaction involving loss of the indolylmethyl side chain.