300790-49-2Relevant academic research and scientific papers
Acid catalysed reactions of ω-mercaptoalkylphosphinic anilides: Reluctance of the thiol group to participate in displacement of the aniline moiety
Harger, Martin J. P.
, p. 296 - 297 (2007/10/03)
Acid catalysed cyclisation occurs readily with HO(CH2)(n+3)P(O)(NHPh)Ph (n = 0 or 1) in MeOH but only acyclic HS(CH2)(n+3)P(O)(OMe)Ph is obtained when HS(CH2)(n+3)P(O)(NHPh)Ph (n = 0 or 1) is treated with HCl in CDCl3 containing 1% MeOH; cyclisation can occur if MeOH is excluded completely but even the five-membered cyclic thiophosphinate 5 (n = 0) is not formed readily.
