30081-72-2

Usage

Uses

Used in Pharmaceutical Industry:
4-hydroxy-2H-isoquinolin-1-one is used as an enzyme inhibitor for its potential therapeutic applications, targeting enzymes involved in various biological processes. Its ability to modulate these processes makes it a promising candidate for the development of new drugs.
Used in Agrochemical Industry:
4-hydroxy-2H-isoquinolin-1-one is used as a building block in the synthesis of various agrochemical compounds, contributing to the development of novel pesticides and other agricultural chemicals.
Used in Antioxidant and Anti-inflammatory Applications:
4-hydroxy-2H-isoquinolin-1-one is used as an antioxidant and anti-inflammatory agent due to its potential biological activities. These properties can be harnessed for the treatment of various conditions and diseases where oxidative stress and inflammation play a significant role.

InChI:InChI=1/C9H7NO2/c11-8-5-10-9(12)7-4-2-1-3-6(7)8/h1-5,11H,(H,10,12)

Upstream product

• 13972-97-9 4-hydroxy-2-methyl-1(2H)-isoquinolone-3-carboxylic acid methyl ester 
• 99357-98-9 2-(2-hydroxyimino-ethyl)-benzoic acid 
• 21201-50-3 2-Hydroxyisocarbostyril 
• 112507-09-2 2-nitro-indan-1,3-dione monooxime 
• 26177-04-8 N-toluenesulfonoxy-isocarbostyril 
• 98591-62-9 1-chloro-3-nitro-isoquinolin-4-ol 

Downstream Products

• 3336-43-4 1-chloro-4-isoquinolinol 
• 1334432-77-7 4-(but-3-enyloxy)isoquinolin-1(2H)-one 
• 1334433-03-2 (1R,2S,4S)-2-isopropyl-4-methylcyclohexyl (3aR,4aS,10bR)-6-oxo-3,3a,4,4a-tetrahydro-2H-furo[2',3':2,3]cyclobuta[1,2-c]isoquinoline-5(6H)-carboxylate 
• 154550-16-0 4-benzyloxycarbonyloxy-2-methyl-1(2H)-isoquinolinone 
• 154550-15-9 4-benzyloxycarbonyloxy-1(2H)-isoquinolinone 
• 15298-58-5 1,4-dichloro-1,2-dihydrocyclobutisoquinoline 

Relevant academic research and scientific papers

Intramolecular [2+2] photocycloaddition of substituted isoquinolones: Enantioselectivity and kinetic resolution induced by a chiral template

From simple to complex: Starting from easily accessible isoquinolones 1 (X=Br, OH), complex cyclobutane photoproducts such as compound 2 can be obtained with high enantioselectivity (88-96% ee) through the use of a chiral template. Compound 3, which was i

Convergent synthesis of 1,1′-biisoquinolines tethered to calamitic subunits

A convergent synthesis of a series of 4,4′-functionalized 1,1′-biisoquinolines via 1-chloro-4-hydroxyisoquinoline and substituted biphenyl- and phenylpyrimidine ethers as building blocks is described. The latter were prepared by Williamson etherification of the respective 4-hydroxybiphenyl and -phenylpyrimidine precursors with dibromoalkanes, allowing variation of the spacer lengths. 1-Chloro-4-hydroxyisoquinoline was obtained from N-phthalimidoglycine ethyl ester through a Gabriel-Colman reaction as a key step. Linkage of the building blocks by etherification in the presence of potassium carbonate gave the isoquinolines, which were submitted to a nickel(II) chloride mediated homocoupling to yield the ligand systems. Georg Thieme Verlag Stuttgart.