3336-43-4

Usage

Uses

Used in Pharmaceutical Industry:
1-CHLORO-4-HYDROXYISOQUINOLINE 97 is used as a key intermediate in the synthesis of various drugs and pharmaceutical products, particularly for the development of antimalarial and antitumor medications. Its unique structure and reactivity contribute to the creation of new drug molecules with improved therapeutic properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-CHLORO-4-HYDROXYISOQUINOLINE 97 serves as a building block for the synthesis of other organic compounds. Its versatile nature allows for the development of novel drug candidates with potential applications in treating various diseases and conditions.
Used in Drug Discovery:
1-CHLORO-4-HYDROXYISOQUINOLINE 97 plays a crucial role in drug discovery, where it is utilized to explore new chemical entities and optimize existing drug structures. Its presence in the synthesis process can lead to the discovery of innovative therapeutic agents with enhanced efficacy and safety profiles.

Upstream product

• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 30081-72-2 1,4-dihydroxyisoquinoline 
• 3336-60-5 1-chloro-4-methoxyisoquinoline 
• 30081-72-2 4-hydroxy-1(2H)-isoquinolinone 

Downstream Products

• 106488-49-7 6-chloro-3,4-dihydro-3-phenyl-2H-1,3-oxazino<5,6-c>isoquinoline 
• 1078719-74-0 1-chloro-4-({10-[(4'-octyl-1,1'-biphenyl-4-yl)oxy]decyl}oxy)isoquinoline 
• 1078719-76-2 1-chloro-4-({6-[4-(2-octylpyrimidin-5-yl)phenoxy]hexyl}oxy)isoquinoline 
• 1078719-99-9 1-chloro-4-{6-[4-(hexyloxy)phenoxy]hexyloxy}isoquinoline 
• 1078720-00-9 1-chloro-4-{6-[4-(octyloxy)phenoxy]hexyloxy}isoquinoline 
• 1078719-73-9 1-chloro-4-({6-[(4'-octyl-1,1'-biphenyl-4-yl)oxy]hexyl}oxy)isoquinoline 
• 1078719-97-7 1-chloro-4-{4-[4-(hexyloxy)phenoxy]butoxy}isoquinoline 
• 1078719-98-8 1-chloro-4-{4-[4-(octyloxy)phenoxy]butoxy}isoquinoline 
• 1078719-75-1 4'-({6-[(1-chloroisoquinolin-4-yl)oxy]hexyl}oxy)-1,1'-biphenyl-4-carbonitrile 
• 1201762-65-3 1-chloroisoquinolin-4-yl 4-(hexadecyloxy)benzoate 
• 1375352-75-2 3-amino-1-(3-bromo-4,5-dimethoxy-phenyl)-9-chloro-1H-4-oxa-10-aza-phenanthrene-2-carbonitrile 
• 1375352-92-3 3-amino-1-(3-bromo-4,5-dimethoxy-phenyl)-9-methylamino-1H-4-oxa-10-aza-phenanthrene-2-carbonitrile 
• 3336-60-5 1-chloro-4-methoxyisoquinoline 
• 4903-73-5 1-chloro-4-(phenylmethoxy)isoquinoline 

Relevant academic research and scientific papers

Convergent synthesis of 1,1′-biisoquinolines tethered to calamitic subunits

A convergent synthesis of a series of 4,4′-functionalized 1,1′-biisoquinolines via 1-chloro-4-hydroxyisoquinoline and substituted biphenyl- and phenylpyrimidine ethers as building blocks is described. The latter were prepared by Williamson etherification of the respective 4-hydroxybiphenyl and -phenylpyrimidine precursors with dibromoalkanes, allowing variation of the spacer lengths. 1-Chloro-4-hydroxyisoquinoline was obtained from N-phthalimidoglycine ethyl ester through a Gabriel-Colman reaction as a key step. Linkage of the building blocks by etherification in the presence of potassium carbonate gave the isoquinolines, which were submitted to a nickel(II) chloride mediated homocoupling to yield the ligand systems. Georg Thieme Verlag Stuttgart.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.