3336-43-4

Basic information

• Product Name: 1-CHLORO-4-HYDROXYISOQUINOLINE 97
• Synonyms: 1-CHLORO-4-HYDROXYISOQUINOLINE 97;1-Chloroisoquinolin-4-ol
• CAS NO: 3336-43-4
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.605
• Product Categories: Halogenated Heterocycles;Heterocyclic Building Blocks;Isoquinolines;IsoquinolinesBuilding Blocks
• Mol File: 3336-43-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 184-188 °C(lit.)
• Boiling Point: 454.8 °C at 760 mmHg
• Flash Point: 228.9 °C
• Appearance: /
• Density: 1.412
• CAS DataBase Reference: 1-CHLORO-4-HYDROXYISOQUINOLINE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-4-HYDROXYISOQUINOLINE 97(3336-43-4)
• EPA Substance Registry System: 1-CHLORO-4-HYDROXYISOQUINOLINE 97(3336-43-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 3336-43-4(Hazardous Substances Data)

Usage

General Description

1-CHLORO-4-HYDROXYISOQUINOLINE 97 is a chemical compound with the molecular formula C9H6ClNO. It is a chlorinated derivative of hydroxyisoquinoline and is commonly used in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical products. 1-CHLORO-4-HYDROXYISOQUINOLINE 97 has a wide range of applications, including as an intermediate in the production of antimalarial and antitumor drugs. It is also used as a building block for the synthesis of other organic compounds and plays a crucial role in the development of new drug molecules. 1-CHLORO-4-HYDROXYISOQUINOLINE 97 is a valuable chemical in the field of medicinal chemistry and drug discovery due to its versatile reactivity and potential therapeutic applications.

Upstream product

• 30081-72-2 4-hydroxy-1(2H)-isoquinolinone 
• 3336-60-5 1-chloro-4-methoxyisoquinoline 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 30081-72-2 1,4-dihydroxyisoquinoline 

Downstream Products

• 106488-49-7 6-chloro-3,4-dihydro-3-phenyl-2H-1,3-oxazino<5,6-c>isoquinoline 
• 1078719-74-0 1-chloro-4-({10-[(4'-octyl-1,1'-biphenyl-4-yl)oxy]decyl}oxy)isoquinoline 
• 1078719-76-2 1-chloro-4-({6-[4-(2-octylpyrimidin-5-yl)phenoxy]hexyl}oxy)isoquinoline 
• 1078719-99-9 1-chloro-4-{6-[4-(hexyloxy)phenoxy]hexyloxy}isoquinoline 
• 1078720-00-9 1-chloro-4-{6-[4-(octyloxy)phenoxy]hexyloxy}isoquinoline 
• 1078719-73-9 1-chloro-4-({6-[(4'-octyl-1,1'-biphenyl-4-yl)oxy]hexyl}oxy)isoquinoline 
• 1078719-97-7 1-chloro-4-{4-[4-(hexyloxy)phenoxy]butoxy}isoquinoline 
• 1078719-98-8 1-chloro-4-{4-[4-(octyloxy)phenoxy]butoxy}isoquinoline 
• 1078719-75-1 4'-({6-[(1-chloroisoquinolin-4-yl)oxy]hexyl}oxy)-1,1'-biphenyl-4-carbonitrile 
• 1375352-92-3 3-amino-1-(3-bromo-4,5-dimethoxy-phenyl)-9-methylamino-1H-4-oxa-10-aza-phenanthrene-2-carbonitrile 
• 3336-60-5 1-chloro-4-methoxyisoquinoline 
• 1375352-75-2 3-amino-1-(3-bromo-4,5-dimethoxy-phenyl)-9-chloro-1H-4-oxa-10-aza-phenanthrene-2-carbonitrile 
• 1201762-65-3 1-chloroisoquinolin-4-yl 4-(hexadecyloxy)benzoate 
• 4903-73-5 1-chloro-4-(phenylmethoxy)isoquinoline 

Relevant articles and documents

Convergent synthesis of 1,1′-biisoquinolines tethered to calamitic subunits

A convergent synthesis of a series of 4,4′-functionalized 1,1′-biisoquinolines via 1-chloro-4-hydroxyisoquinoline and substituted biphenyl- and phenylpyrimidine ethers as building blocks is described. The latter were prepared by Williamson etherification of the respective 4-hydroxybiphenyl and -phenylpyrimidine precursors with dibromoalkanes, allowing variation of the spacer lengths. 1-Chloro-4-hydroxyisoquinoline was obtained from N-phthalimidoglycine ethyl ester through a Gabriel-Colman reaction as a key step. Linkage of the building blocks by etherification in the presence of potassium carbonate gave the isoquinolines, which were submitted to a nickel(II) chloride mediated homocoupling to yield the ligand systems. Georg Thieme Verlag Stuttgart.