300830-83-5

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-methoxy-4-quinolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-
• CAS NO: 300830-83-5
• Molecular Formula: C21H26N2O6
• Molecular Weight: 402.447
• Mol File: 300830-83-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-methoxy-4-quinolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-methoxy-4-quinolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-(300830-83-5)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-methoxy-4-quinolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-(300830-83-5)

Safety Data

• Hazardous Substances Data: 300830-83-5(Hazardous Substances Data)

Upstream product

• 82121-05-9 4-hydroxy-7-methoxyquinoline 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 

Relevant articles and documents

Potent inhibitors of the hepatitis C virus NS3 protease: Design and synthesis of macrocyclic substrate-based β-strand mimics

The virally encoded NS3 protease is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma. The design and synthesis of 15-membered ring β-strand mimics which are capable of inhibiting the interactions between the HCV NS3 protease enzyme and its polyprotein substrate will be described. The binding interactions between a macrocyclic ligand and the enzyme were explored by NMR and molecular dynamics, and a model of the ligand/enzyme complex was developed.