300856-35-3

Upstream product

• 6373-46-2 p-benzyloxyaniline 
• 98045-03-5 α-methyl N-(tert-butoxycarbonyl)aspartate 
• 130622-08-1 dimethyl N-tert-butoxycarbonyl-L-aspartate 

Downstream Products

• 300856-37-5 (S)-tert-Butoxycarbonylamino-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-acetic acid methyl ester 
• 648415-10-5 (S)-Acetylamino-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-acetic acid methyl ester 
• 300856-38-6 (S)-Amino-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-acetic acid methyl ester 
• 300856-36-4 (S)-tert-Butoxycarbonylamino-[(R)-1-(4-hydroxy-phenyl)-2-oxo-pyrrolidin-3-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE)

New inhibitors of tumor necrosis factor-α converting enzyme (TACE) were discovered using an N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamide scaffold. The series was found to be potent in a porcine TACE (pTACE) assay with IC50s typically below 5 nM.