3009-34-5

Usage

Uses

Used in Pharmaceutical Industry:
1,4-Benzoquinoneimine is used as an impurity in Acetaminophen, which is an analgesic and antipyretic drug. Acetaminophen is commonly used to treat headache, muscle aches, arthritis, and other acute or chronic painful conditions. The presence of 1,4-Benzoquinoneimine in Acetaminophen may contribute to its therapeutic effects, but it is also important to monitor and control its levels to ensure the safety and efficacy of the drug.

Safety Profile

Experimental reproductiveeffects. The solid decomposes violently (nearlyexplosive).When heated to decomposition it emits toxicfumes of NOx.

InChI:InChI=1/C6H5NO/c7-5-1-3-6(8)4-2-5/h1-4,7H

Upstream product

• 99-98-9 4-amino-N,N-dimethylaniline 
• 33624-86-1 Wursters Rot 
• 178100-44-2 p-(acetyl-N-methyl)aminophenyl azide 
• 88-75-5 2-hydroxynitrobenzene 
• 120089-55-6 4-hydroxyphenylpentazole 
• 1073-71-8 4-hydroxyphenyldiazonium chloride 
• 51-78-5 p-aminophenol hydrochloride 
• 2198-58-5 N,N-diethyl-1,4-phenylenediamine dihydrochloride 
• 536-46-9 4-dimethylaminophenylamine dihydrochloride 
• 93-05-0 N,N-diethylaniline 
• 637-61-6 benzoquinone N-chloroimine 
• 123-30-8 4-amino-phenol 
• 7575-35-1 N,N-bis(2-hydroxyethyl)-4-aminoaniline 

Downstream Products

• 2150-58-5 phenol blue 
• 123-30-8 4-amino-phenol 
• 7664-41-7 ammonia 
• 106-51-4 p-benzoquinone 
• 24093-23-0 N¹--2-amino-p-benzochinon-diimin 
• 6245-87-0 [1,4]benzoquinone-mono-(4-amino-phenylimine) 

Relevant academic research and scientific papers

Redox-active gold nanoparticle-encapsulated poly(amidoamine) dendrimer for electrochemical sensing of 4-aminophenol

Metal nanoparticle-encapsulated with dendrimer networks have gained enormous interest towards fabrication of various electrochemical devices, including electrochemical sensors. In this work, we have designed a redox active electrochemical sensor using fer

3D multiporous Co,N co-doped MoO2/MoC nanorods hybrids as improved electrode materials for highly sensitive simultaneous determination of acetaminophen and 4-aminophenol

3D multiporous Co, N co-doped MoO2/MoC (3D Co,N-MoO2/MoC) nanorods hybrids were successfully synthesized via carburizing core-shell ZIF-67-cladded MoO3 nanorods precursor at high temperature. As-fabricated Co,N-MoO2/MoC nanorods coated glassy carbon electrodes (GCE) was demonstrated to possess superior electrocatalytic activity for the electro-oxidation of acetaminophen (AC) and 4-aminophenol (4-AP). Such excellent electrochemical performance was largely attributed to the synergistic effect of the unique multiporous structure, the optimal component and abundant active sites of the nanorods. The corresponding electrode reaction mechanisms were studied in detail in this article. Under optimal conditions, the linear detection ranges were 0.05–200.0 μmol/L for AC and 0.05–140.0 μmol/L for 4-AP, respectively, with the low detection limits of 0.013 μmol/L and 0.012 μmol/L. Furthermore, the 3D Co,N-MoO2/MoC/GCE revealed excellent sensitivity, good reproducibility, stability and anti-interference ability. The developed electrode was evaluated towards the detecting AC and 4-AP in biological fluids, environment water and pharmaceutical formulations with satisfactory recovery, which had a broad application prospect.

A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells

A new fluorescence probe was developed for HClO detection under physiological conditions, which displayed fast response (t1/2 1000-fold) toward HClO with high sensitivity and selectivity. The probe was successfully applied for the detection of both exogenous and endogenous HClO in living cells. Using the probe-based tool, we could observe the H2S-induced HClO biogenesis in living cells for the first time.

P-Aminophenol sensor based on tetra-β-[3-(dimethylamine)phenoxy] phthalocyanine cobalt(ii)/multiwalled carbon nanotube hybrid

A highly efficient catalyst is a key challenge for developing electrochemical sensors for p-aminophenol (4-AP), which widely exists in the environment. In this paper, we describe a feasible synthesis for a tetra-β-[3-(dimethylamine)phenoxy] phthalocyanine

Electrochemical Detection of Escherichia coli from Aqueous Samples Using Engineered Phages

In this study, an enzyme-based electrochemical method was developed for the detection of Escherichia coli (E. coli) using the T7 bacteriophages engineered with lacZ operon encoding for beta-galactosidase (β-gal). The T7lacZ phages can infect E. coli, and have the ability to trigger the overexpression of β-gal during the infection of E. coli. The use of the engineered phages resulted in a more sensitive detection of E. coli by (1) overexpression of β-gal in E. coli during the specific infection and (2) release of the endogenous intracellular β-gal from E. coli following infection. The endogenous and phage-induced β-gal was detected using the electrochemical method with 4-aminophenyl-β-galactopyranoside (PAPG) as a substrate. The β-gal catalyzed PAPG to an electroactive species p-aminophenol (PAP) which could be monitored on an electrode. The electrochemical signal was proportional to the concentration of E. coli in the original sample. We demonstrated the application of our strategy in aqueous samples (drinking water, apple juice, and skim milk). Using this method, we were able to detect E. coli at the concentration of approximately 105 CFU/mL in these aqueous samples in 3 h and 102 CFU/mL after 7 h. This strategy has the potential to be extended to detect different bacteria using specific bacteriophages engineered with gene encoding for appropriate enzymes.

A De Novo Heterodimeric Due Ferri Protein Minimizes the Release of Reactive Intermediates in Dioxygen-Dependent Oxidation

Metalloproteins utilize O2 as an oxidant, and they often achieve a 4-electron reduction without H2O2 or oxygen radical release. Several proteins have been designed to catalyze one or two-electron oxidative chemistry, but t

Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins

Using the single-chain due ferri (DFsc) peptide scaffold, the differential oxidase and oxygenase reactivities of two 4A→4G variants, one with two histidines at the diiron center (G4DFsc) and the other with three histidines (3His-G4DFsc(Mut3)), are explore

The photochemistry of an aryl pentazole in liquid solutions: The anionic 4-oxidophenylpentazole (OPP)

This paper reports a study on the photolysis of an aryl pentazole in solution. 4-Oxidophenylpentazole (OPP) was irradiated in water and in acetonitrile at its first absorption band (320 and 370 nm, respectively) and at 193 nm. 4-Oxidophenylazide (OPA) was

Au(iii)-promoted polyaniline gold nanospheres with electrocatalytic recycling of self-produced reactants for signal amplification

A novel and redox-active nanocatalyst, Au(iii)-promoted polyaniline gold nanosphere (GPANG), was designed as the nanolabel for highly efficient electrochemical immunoassay of human IgG by coupling with electrocatalytic recycling of self-produced reactants.

Palladium-catalyzed silane/siloxane reductions in the one-pot conversion of nitro compounds into their amines, hydroxylamines, amides, sulfonamides, and carbamates

A combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS) facilitates the room-temperature reduction of aromatic nitro compounds to anilines. These reactions tend to be quick (30 min), high-yielding, and tolerate a range of other functional groups. Replacement of PMHS/KF with triethylsilane allows for the reduction of aliphatic nitro compounds to their corresponding hydroxylamines. Depending on the substrate, both conditions can allow for the in situ conversion of the product amines into amides, sulfonamides, and carbamates. Georg Thieme Verlag Stuttgart.