30095-45-5

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 140-67-0 Estragole 
• 123-11-5 4-methoxy-benzaldehyde 
• 101823-08-9 (5,6-Dihydro-[1,4]dioxin-2-yl)-(4-methoxy-phenyl)-methanol 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 27473-38-7 1-diazo-3-(4-methoxyphenyl)propan-2-one 

Relevant academic research and scientific papers

Chemical synthesis of coelenterazine and its analogs: New route by four segment-couplings

A novel and improved synthetic route includes four segment-couplings toward coelenterazine and its analogs as luminescent molecules. Regio- and chemo-selective cross coupling reactions using palladium catalysts with 5-iodo-3-bromo-2-aminopyrazine have enabled providing various aminopyrazine derivatives having different substituents. The improved synthesis of coelenterazine and its analogs employed advanced condensation with the aminopyrazines using various keto-acetal segments, which resulted in much higher yields to give the final imidazopyrazinone heterocycles than the previous method using keto-aldehydes.

Chemistry of 1,4-dioxene II. A new method for the two-carbon homologation of aldehydes and ketones to α-hydroxymethyl ketones

1,4-Dioxen-2-yl lithium 2 reacts with ketones or aldehydes to give alcohols 3 which lead after an allylic rearrangement under mild conditions, followed by reduction and hydrolysis to α-hydroxymethyl ketones in fair yields.