30095-79-5

Basic information

• Product Name: 4H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-NITRO-4-OXO-, ETHYL ESTER
• Synonyms: 4H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-NITRO-4-OXO-, ETHYL ESTER;ethyl 6-nitro-4-oxo-4H-1-benzopyran-2-carboxylate;6-Nitro-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester
• CAS NO: 30095-79-5
• Molecular Formula: C₁₂H₉NO₆
• Molecular Weight: 263.20296
• EINECS: 250-047-8
• Mol File: 30095-79-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 178-179 °C
• Boiling Point: 413.5°Cat760mmHg
• Flash Point: 191.2°C
• Appearance: /
• Density: 1.453g/cm³
• Vapor Pressure: 4.78E-07mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 4H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-NITRO-4-OXO-, ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-NITRO-4-OXO-, ETHYL ESTER(30095-79-5)
• EPA Substance Registry System: 4H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-NITRO-4-OXO-, ETHYL ESTER(30095-79-5)

Safety Data

• Hazardous Substances Data: 30095-79-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H9NO6/c1-2-18-12(15)11-6-9(14)8-5-7(13(16)17)3-4-10(8)19-11/h3-6H,2H2,1H3

Upstream product

• 100-02-7 4-nitro-phenol 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 118-93-4 o-hydroxyacetophenone 
• 14736-31-3 ethyl 4-oxo-4H-1-benzopyran-2-carboxylate 
• 1450-76-6 1-(2-hydroxy-5-nitrophenyl)ethanone 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 30095-81-9 ethyl 6-amino-4-oxo-4H-chromene-2-carboxylate 

Relevant articles and documents

An efficient construction of 4-OXO-4H-chromene-2-carboxylate derivatives via one-pot cascade reaction under solvent-free conditions

An efficient synthetic strategy to chromone derivatives from commercially available diethyl acetylenedicarboxylate and phenols via a one-pot cascade reaction has been developed. Performing the reaction using pyridine and polyphosphoric acid as the catalyst at room temperature and 90°C without any solvent gave the chromone derivatives in good to high yields at one time. A possible reaction pathway was also proposed and supported by the experiment. This protocol is environmentally friendly and metal-free, with advantages including short reaction times, convenient operation, and mild reaction conditions.

Design, synthesis, and inhibitory activity of potent, photoswitchable mast cell activation inhibitors

Allergic reactions affect millions of people worldwide. The need for new and effective antiallergic agents is evident, and insight into the underlying mechanisms that lead to allergic events is necessary. Herein, we report the design, synthesis, and activity of photoswitchable mast cell activation inhibitors. In mast cell degranulation assays, these inhibitors possess significantly greater potency than an original, chromone-based antiallergic agent. Furthermore, one of the photoswitchable inhibitors shows a significant difference in inhibitory activity between its two photoisomeric forms. Further optimization could ultimately lead to a photoswitchable compound suitable for studying mechanisms involved in allergic reactions in a novel manner, with activity addressable by light and with precise spatiotemporal control over events at the molecular level.

Benzopyrones. 7. Synthesis and antiallergic activity of some 2-(5-tetrazolyl)chromones.

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