30113-70-3

Basic information

• Product Name: 3-(2-hydroxy-3-methoxybenzylidene)chroman-2,4-dione
• CAS NO: 30113-70-3
• Molecular Weight: 296.279
• Mol File: 30113-70-3.mol

Chemical Properties

• CAS DataBase Reference: 3-(2-hydroxy-3-methoxybenzylidene)chroman-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxy-3-methoxybenzylidene)chroman-2,4-dione(30113-70-3)
• EPA Substance Registry System: 3-(2-hydroxy-3-methoxybenzylidene)chroman-2,4-dione(30113-70-3)

Safety Data

• Hazardous Substances Data: 30113-70-3(Hazardous Substances Data)

Upstream product

• 4438-85-1 3H-chromene-2,4-dione 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 108-95-2 phenol 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 

Downstream Products

• 1338247-98-5 5-(2-hydroxy-3-methoxyphenyl)-2,3-dihydro-1Hchromeno[4,3-e][1,4]thiazepin-6(5H)-one 
• 101937-22-8 3-((Ξ)-2-acetoxy-3-methoxy-benzylidene)-chroman-2,4-dione 

Relevant articles and documents

Structure-based design, synthesis and biological evaluation of β-glucuronidase inhibitors

Using structure-based virtual screening approach, a coumarin derivative (1) was identified as β-glucuronidase inhibitor. A focused library of coumarin derivatives was synthesized by eco-benign version of chemical reaction, and all synthetic compounds were

Coumarin-Based Bioactive Compounds: Facile Synthesis and Biological Evaluation of Coumarin-Fused 1,4-Thiazepines

As part of our ongoing studies on the synthesis of bioactive coumarin compounds, we synthesized a series of new coumarin-fused 1,4-thiazepines using a simple method. The biological activity of target compounds along with 3-(2-hydroxybenzylidene)chroman-2,4-dione intermediates was screened by evaluation of their antioxidant and cytotoxic activities. The antioxidant activity was assessed using two methods, namely, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method and ferric reducing antioxidant power (FRAP) assay. 4-Methoxyphenolic compound 5d in thiazepine series showed the most potent scavenging activity, while the 4-bromophenolic derivative 5b was the most efficient compound in FRAP assay. Also, the result of cytotoxic evaluation using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay demonstrated that compound 5b is at least twofold more potent than etoposide against MCF-7, SK-N-MC, and MDA-MB 231 cell lines. A series of new coumarin-fused 1,4-thiazepines were synthesized using a simple method. The biological activities of target compounds were screened by evaluation of their antioxidant and cytotoxic activities.