301179-69-1Relevant articles and documents
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead
Liu,Link,Pei,Reilly,Leitza,Nguyen,Marsh,Okasinski,Von Geldern,Ormes,Fowler,Gallatin
, p. 4025 - 4040 (2000)
The interaction between leukocyte function-associated antigen-1 (LFA-1), a member of the β2-integrin family of adhesion molecules, and intracellular adhesion molecule ICAM-1 (cd54) is thought to play a critical role in the inflammatory process.
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
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Page 35, (2010/02/07)
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.