301179-91-9

Upstream product

• 140-88-5 ethyl acrylate 
• 306988-01-2 2,3-di(trifluoromethyl)-4-iodophenol 
• 306987-88-2 (4-hydroxy-2,3-bis-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester 

Downstream Products

• 306988-12-5 4-(E-2-ethoxycarbonylvinyl)-2,3-di(trifluoromethyl)phenyl trifluoromethanesulfonate 
• 301179-92-0 ethyl E-4-(trifluoromethanesulfonyl)-2,3-bis(trifluoromethyl)cinnamate 

Relevant academic research and scientific papers

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Diels-Alder reactions of hexafluoro-2-butyne with 2-heterosubstituted furans: A facile and general synthesis of 1,4-disubstituted 2,3-di(trifluoromethyl)benzenes

(matrix presented) An electron-donating heteroatom substituent at position-2 of a furan promotes regiospecific opening of the 7-oxa bridge of the Diels-Alder cycloadduct with hexafluoro-2-butyne, producing a 4-heterosubstituted 2,3-di(trifluoromethyl)phenol building block in a single step. The phenol and heteroatom substituent are easily transformed to the corresponding iodide or triflate that readily undergoes Heck, Suzuki, and Stille reactions to install a variety of substituents in high yields. This methodology provides a facile and general synthesis of 1,4-disubsituted 2,3-di(trifluoromethyl)benzenes.