301346-20-3

Upstream product

• 188290-11-1 (5S)-5-(4-methoxybenzyloxymethyl)tetrahydro-2-furanone 
• 6893-26-1 D-Glutamic acid 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 

Downstream Products

• 301346-37-2 1-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentyloxymethyl]-4-methoxy-benzene 
• 301346-38-3 (S)-5-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)pentan-1-ol 
• 301346-39-4 5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal 
• 637742-27-9 (2E,6E,8E)-(4R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-oxo-docosa-2,6,8-trienoic acid (S)-3-carboxy-1-(4-methoxy-benzyloxymethyl)-propyl ester 
• 637742-24-6 (2E,6E,8E)-(4R,5R,10S,11R,12S)-5-Hydroxy-11-(4-methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-docosa-2,6,8-trienoic acid (S)-4-hydroxy-1-(4-methoxy-benzyloxymethyl)-butyl ester 
• 301346-35-0 (2S)-2,5-bis-(tert-butyldimethylsilyloxy)-1-(4-methoxybenzyloxy)pentane 
• 301346-36-1 (2S)-1-(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol 

Relevant academic research and scientific papers

Chemistry and biology of khafrefungin. Large-scale synthesis, design, and structure-activity relationship of khafrefungin, an antifungal agent

Large-scale synthesis, design, and structure-activity relationships of khafrefungin are reported. Khafrefungin is an antifungal agent that inhibits inositol phosphorylceramide (IPC) synthase, a enzyme involved in fungal sphingolipid biosynthesis. Unlike o

First total synthesis of Aspinolide B, a new pentaketide produced by Aspergillus ochraceus

The first asymmetric total synthesis of Aspinolide B (1), a new 10-membered lactone discovered by chemical screening methods in the cultures of Aspergillus ochraceus, has been accomplished. The key steps included a selective Felkin-type addition of TMS-acetylene to aldehyde 3a and a Nozaki-Hiyama-Kishi coupling reaction to build the required 10-membered ring. This synthesis confirmed the absolute stereochemistry of aspinolide B, established through Helmchen's method and corrected its previously reported specific optical rotation.