301350-41-4Relevant academic research and scientific papers
Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents
Holla, B. Shivarama,Malini,Rao, B. Sooryanarayana,Sarojini,Kumari, N. Suchetha
, p. 313 - 318 (2007/10/03)
A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen.
