56300-69-7

Basic information

• Product Name: 5-(2 4-DICHLOROPHENYL)FURFURAL 97
• Synonyms: 5-(2 4-DICHLOROPHENYL)FURFURAL 97;5-(2,4-Dichlorophenyl)furfural 97%;5-(2,4-dichlorophenyl)-2-furancarboxaldehyde
• CAS NO: 56300-69-7
• Molecular Formula: C₁₁H₆Cl₂O₂
• Molecular Weight: 241.072
• Product Categories: Building Blocks;Furans;FuransHeterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Aldehydes;Building Blocks;C10-C12;C8 to C11;C9 to C11;Carbonyl Compounds;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Organic Building Blocks
• Mol File: 56300-69-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 158-163 °C(lit.)
• Boiling Point: 359.7°C at 760 mmHg
• Flash Point: 171.3°C
• Appearance: /
• Density: 1.392g/cm³
• Vapor Pressure: 2.33E-05mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: 5-(2 4-DICHLOROPHENYL)FURFURAL 97(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2 4-DICHLOROPHENYL)FURFURAL 97(56300-69-7)
• EPA Substance Registry System: 5-(2 4-DICHLOROPHENYL)FURFURAL 97(56300-69-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 56300-69-7(Hazardous Substances Data)

Usage

General Description

5-(2,4-Dichlorophenyl)Furfural 97 is a synthetic chemical compound with the formula C12H6Cl2O2. 5-(2 4-DICHLOROPHENYL)FURFURAL 97 falls into the category of organic compounds known as organochlorides. It is characterized by a furan ring, which is a heterocyclic compound consisting of a five-member aromatic ring with four carbon atoms and one oxygen atom, substituted with a dichlorophenyl moiety. With a purity of 97%, it is generally used in scientific research for various purposes. Its exact use or application greatly depends on the specific area of research or study.

InChI:InChI=1/C11H6Cl2O2/c12-7-1-3-9(10(13)5-7)11-4-2-8(6-14)15-11/h1-6H

Upstream product

• 98-01-1 furfural 
• 554-00-7 2,4-Dichloroaniline 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 27329-70-0 5-formylfurane-2-boronic acid 
• 29898-32-6 2,4-dichloro-1-iodo-benzene 
• 50-84-0 2,4 dichlorobenzoic acid 

Downstream Products

• 269740-04-7 C₂₆H₁₈Cl₄N₄O₄ 
• 1391113-83-9 C₂₂H₁₉Cl₂N₃O₃S 
• 1391113-99-7 2-[1-{5-(5-(2,4-dichlorophenyl)furan-2-yl)-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazolyl}]-4-(4-nitrophenyl)[1,3]thiazole 
• 1391113-70-4 C₂₁H₁₆Cl₂O₄ 

Relevant articles and documents

5-Aryl-2-furaldehydes in the synthesis of tetrahydropyrimidinones by Biginelli reaction

5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)- urea in the presence of FeCl3·6H2O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine- 5-carboxylates was obtained.

Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans

Phenotypic HTS campaigns with a blood stage malaria assay have been used to discover novel chemotypes for malaria treatment with potential alternative mechanisms of action compared to existing agents. N1-(5-(3-Chloro-4-fluorophenyl)furan-2-yl)-N3,N3-dimethylpropane-1,3-diamine, 1 was identified as a modest inhibitor of P. falciparum NF54 (IC50= 875 nM) with an apparent long plasma half-life after high dose oral administration to mice, although the compound later showed poor metabolic stability in liver microsomes through ring- and side chain-oxidation and N-dealkylation. We describe here the synthesis of derivatives of 1, exploring the influence of substitution patterns around the aromatic ring, variations on the alkyl chain and modifications in the core heterocycle, in order to probe potency and metabolic stability, where 4k showed a long half-life in rats.

Palladium-catalyzed decarboxylative C-H bond arylation of furans

A Pd/PCy3/Ag2CO3 (Cy = cyclohexyl) catalytic system was found to promote decarboxylative arylation through the combination of decarboxylation and C-H bond functionalization. This protocol features a good substrate scope of