301353-96-8 Usage
Biochem/physiol Actions
P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.
References
1) Pieper et al. (2010), Discovery of a proneurogenic, neuroprotective chemical; Cell, 142 39
2) Tesla et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis; Proc. Natl. Acad. Sci. USA, 109 17016
3) De Jesus-Cortes et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease; Proc. Natl. Acad. Sci. USA, 109 17010
4) Latchney et al. (2015), Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome; Neurosci. Lett. 591 86
5) Wang et al. (2014), P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage; Cell, 158 1324
Check Digit Verification of cas no
The CAS Registry Mumber 301353-96-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,1,3,5 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 301353-96:
(8*3)+(7*0)+(6*1)+(5*3)+(4*5)+(3*3)+(2*9)+(1*6)=98
98 % 10 = 8
So 301353-96-8 is a valid CAS Registry Number.
301353-96-8Relevant academic research and scientific papers
Discovery of Inhibitors of MicroRNA-21 Processing Using Small Molecule Microarrays
Connelly, Colleen M.,Boer, Robert E.,Moon, Michelle H.,Gareiss, Peter,Schneekloth, John S.
, p. 435 - 443 (2017/02/26)
The identification of small molecules that bind to and perturb the function of microRNAs is an attractive approach for the treatment for microRNA-associated pathologies. However, there are only a few small molecules known to interact directly with microRN
