30153-85-6

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-CHLOROBENZYL)-1H-PYRAZOL-5-AMINE HYDROCHLORIDE is used as an intermediate in the synthesis of various pharmaceutical drugs. Its unique chemical structure and properties make it a valuable building block for the development of new medications, potentially leading to the creation of innovative treatments for various health conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-CHLOROBENZYL)-1H-PYRAZOL-5-AMINE HYDROCHLORIDE serves as a key component in the development of new agrochemicals. Its potential applications include the creation of novel pesticides, herbicides, and other agricultural products that can improve crop yield and protect plants from harmful pests and diseases.
Overall, 1-(4-CHLOROBENZYL)-1H-PYRAZOL-5-AMINE HYDROCHLORIDE is a versatile chemical compound with a broad range of potential applications in both the pharmaceutical and agrochemical industries. Its unique properties and enhanced solubility make it an attractive candidate for the development of new and important products that can address various challenges in these fields.

InChI:InChI=1/C10H10ClN3/c11-9-3-1-8(2-4-9)7-14-10(12)5-6-13-14/h1-6H,7,12H2

Upstream product

• 42066-41-1 p-Chlor-benzaldehyd-N-(2-cyan-aethyl)-hydrazon 
• 1820-80-0 3-aminopyrazole 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

The effective treatment for dengue virus infection continues to be a challenge. We herein reported our continued SAR exploration on the spiropyrazolopyridone scaffold. Introducing different substituents at the 3?- or 5?-site of the pyrazolopyridone core or moving the benzyl chain to the adjacent nitrogen led to a significant loss of potency on DENV-2. While a narrow range of substitutions were tolerated at the para-position of the phenyl ring, di-substitution on the phenyl ring is beneficial for DENV-2 potency and has variable influences on DENV-3 potency depending on the exact compound. Among these molecules, compounds 22 (JMX0376) with 4-chloro-3-fluorobenzyl and 24 (JMX0395) with 2,4-bis(trifluoromethyl)benzyl showed the most potent and broadest inhibitory activities against DENV-1 to ?3 with nanomolar to low micromolar EC50 values.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

Approach to the library of fused pyridine-4-carboxylic acids by combes-type reaction of acyl pyruvates and electron-rich amino heterocycles

A library of fused pyridine-4-carboxylic acids (including pyrazolo[3,4-b]pyridines, isoxazolo[5,4-b]pyridines, furo[2,3-b]pyridines, thieno[2,3-b]pyridines, and pyrido[2,3-d]pyrimidines) was generated by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles followed by hydrolysis of the ester. The library members were also demonstrated to undergo the standard combinatorial transformations including amide coupling and esterification, as well as less common heterocyclizations to 1,2,4-triazoles and 1,2,4-oxadiazoles.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.