301541-46-8

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 301541-33-3 N-benzyl-2-chloro-N-(2-oxo-propyl)-acetamide 
• 27159-32-6 3-benzylaminopropan-2-ol 
• 100-39-0 benzyl bromide 

Downstream Products

• 301541-47-9 (R)-1-Benzyl-5-methyl-piperazin-2-one 

Relevant academic research and scientific papers

Efficient synthesis of substituted piperazinones via tandem reductive amination-cyclization

A new strategy for the preparation of substituted piperazinones features a tandem reductive coupling and S(N)2-cyclization of a 2-chloro-N-(2-oxoalkyl)acetamide (1) and a primary amine (2). The method is convenient for diversity-oriented synthesis, since a wide variety of amines may be used in the ring-forming reaction to produce N-substituted piperazinones (3). (C) 2000 Published by Elsevier science Ltd.