30161-03-6

Upstream product

• 849403-88-9 5-chloro-2-fluoro-3-phenylbenzothiophene 
• 109-72-8 n-butyllithium 
• 7031-25-6 2-(4'-chlorophenylmercapto)acetyl chloride 
• 3405-88-7 (4-chlorophenylthio)acetic acid 
• 28540-36-5 5-chloro-3-phenylbenzo[b]thiophene 
• 65520-25-4 5-chloro-benzo[b]thiophen-3-ol 
• 849403-96-9 trifluoro-methanesulfonic acid 5-chloro-benzo[b]thiophen-3-yl ester 

Relevant academic research and scientific papers

Aromatic ring-opening of 2-fluorobenzothiophenes by alkyllithiums

Diphenylacetylenes are obtained when alkyllithium reagents are added to 3-aryl-2-fluorobenzothiophenes at low temperature. The aromatic ring-opening mechanism involves a nucleophilic addition of the alkyllithium to the sulfur atom of the thiophene. The re