301651-23-0Relevant academic research and scientific papers
Cobaloxime-mediated intramolecular radical addition onto oxime functions in the electrolysis media: Formation of mannich base analogues
Inokuchi,Kawafuchi
, p. 421 - 423 (2001)
Addition of the carbon radical generated from α-bromoacetals onto the O-alkyloximes, affording Mannich base analogues, was achieved by the electrolysis in MeOH containing cobaloxime (catalytic) as a mediator at a Zn sacrificial electrode in an undivided cell. Cyclization proceeded stereoselectively in some cases to afford the 2-alkoxy-3-alkyl-4-aminotetrahydrofurans.
5-exo Radical Cyclization onto 3-Alkoxyketimino-1,6-anhydromannopyranoses. Efficient Preparation of Synthetic Intermediates for (-)-Tetrodotoxin
Noya,Paredes,Ozores,Alonso
, p. 5960 - 5968 (2007/10/03)
Ketoxime ethers at C3 of 1,6-anhydro-β-D-mannopyranose derivatives were found to be useful 5-exo radical traps of alkyl and vinyl radicals generated at a chain tethered to the C2 hydroxyl group, allowing advanced synthetic intermediates for (-)-tetrodotoxin to be prepared from D-mannose in good overall yield.
