301666-61-5

Basic information

• Product Name: ethyl 3-(bromomethyl)picolinate
• Synonyms: ethyl 3-(bromomethyl)picolinate
• CAS NO: 301666-61-5
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.09
• Mol File: 301666-61-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 3-(bromomethyl)picolinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(bromomethyl)picolinate(301666-61-5)
• EPA Substance Registry System: ethyl 3-(bromomethyl)picolinate(301666-61-5)

Safety Data

• Hazardous Substances Data: 301666-61-5(Hazardous Substances Data)

Upstream product

• 4021-07-2 3-methyl-pyridine-2-carboxylic acid 
• 20970-75-6 2-cyano-3-methylpyridine 
• 1003-73-2 3-picoline-N-oxide 
• 58997-10-7 ethyl 3-methylpyridine-2-carboxylate 

Downstream Products

• 1211584-54-1 5,6-dihydro-pyrrolo[3,4-b]pyridin-7-one 
• 301666-62-6 ethyl 3-(cyanomethyl)picolinate 

Relevant articles and documents

NOVEL CLOSTRIDIUM DIFFICILE TOXIN INHIBITORS

The present invention relates to benzodiazepine derivative compounds of formula (I), or pharmaceutically acceptable salts thereof. The present benzodiazepine compounds are useful Clostridium difficile inhibitors in the treatment of Clostridium difficile infection in humans. The present invention provides a pharmaceutical composition containing benzodiazepine compounds of formula (I) and a method of making as well as a method of using the same in treating patients infected with Clostridium difficile infection by administering the same. The compounds of the present invention may be used in combination with additional antibiotics or anti-toxin antibody drugs.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND BENAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME

Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), R1 and R2 represent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or R1 and R2, together with a nitrogen atom to which R1 and R2 are attached, may form a ring; R3 and R4 represent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R2 and R3 may be attached to each other to form -(CH2)m-, -N=CH-, -CH=N-, or -(C1-6 alkyl)C=N-; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group -C(=O)N(R5)R6 or group -C(=O)OR7, R8 is absent or represents a bond, an oxygen atom, a sulfur atom, -SO2-, -SO-, -CH2-CH2-, or - CH=CH-, and R9 and R10 represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents - (CH2)n-, -O-(CH2)i-, or -C(=O)NH-(CH2)i-.

Preparation of some Thiopyranopyridine Derivatives

In the first systematic study of thiopyranopyridines in which the sulphur atom is separated from the pyridine ring by one carbon atom, the four isomeric enol esters, ethyl 5-hydroxy-8H-thiopyranopyridine-6-carboxylate (4b), ethyl 8-hydroxy-5H-thiopyranopyridine-7-carboxylate (5b), and ethyl 4-hydroxy-1H-thiopyrano- and pyridine-3-carboxylate (6b) and (7b), have been synthesised.Improved methods for the preparation of their pyridine precursors are described.With phenylhydrazine, the enol esters (4b) - (7b) give condensed pyrazole derivatives (15) - (18), which have dipolar structures; with hot mineral acid they undergo decarboxylative hydrolysis, to give the corresponding oxothiopyranopyridines (4a) - (7a).