4021-07-2

Basic information

• Product Name: 3-Methylpyridine-2-carboxylic acid
• Synonyms: RARECHEM AL BO 0827;3-METHYLPYRIDINE-2-CARBOXYLIC ACID;3-METHYLPICOLINIC ACID;3-METHYL-2-PYRIDINECARBOXYLIC ACID;3-METHYL-A-PICOLINIC ACID;3-METHYL-ALPHA-PICOLINIC ACID;Methylpicolinicacid;3-METHYL-2-CARBOXYLIC ACID PYRIDINE
• CAS NO: 4021-07-2
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.14
• EINECS: -0
• Product Categories: blocks;Carboxes;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Carboxylic Acids;pyridine;Carboxylic Acids
• Mol File: 4021-07-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 114-118 °C
• Boiling Point: 300.598 °C at 760 mmHg
• Flash Point: 135.597 °C
• Appearance: White to tan/Crystalline Powder
• Density: 1.23 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.11±0.50(Predicted)
• CAS DataBase Reference: 3-Methylpyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methylpyridine-2-carboxylic acid(4021-07-2)
• EPA Substance Registry System: 3-Methylpyridine-2-carboxylic acid(4021-07-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 4021-07-2(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

3-Methylpyridine-2-carboxylic acid (3-MepicH) may be used as a ligand in the synthesis of the following metal complexes:[Cu(3-Mepic)2(4-pic)] where 4-pic=4-picoline and [Cu(3-Mepic)2]·2H2O[Co(3-Mepic)3][Ni(3-Mepic)2(H2O)2]bis(3-methyl-picolinato-κ2 N,O)(1,10-phenanthroline)zinc(II) tetrahydrate

General Description

3-Methylpyridine-2-carboxylic acid, also known as 3-methylpicolinic acid (3-MepicH), is a 3-substituted picolinic acid. The dianion formed by reacting 3-MepicH with lithium diisopropylamide (LDA) can undergo C-alkylation with 3-chlorobenzyl chloride.

Upstream product

• 583-61-9 2,3-Lutidine 
• 55589-47-4 3-methylpyridine-2-carboxaldehyde 

Downstream Products

• 33204-88-5 (4-methoxyphenyl)(3-methylpyridin-2-yl)methanol 
• 1133854-47-3 N-benzyl-3-methylpicolinamide 
• 1254364-35-6 C₃₁H₃₉BN₄O₇ 
• 28489-52-3 2,6-diphenyl-3-methylpyridine 
• 18368-76-8 2 chloro-3-methylpyridine 
• 58997-10-7 ethyl 3-methylpyridine-2-carboxylate 

Relevant articles and documents

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND BENAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME

Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), R1 and R2 represent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or R1 and R2, together with a nitrogen atom to which R1 and R2 are attached, may form a ring; R3 and R4 represent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R2 and R3 may be attached to each other to form -(CH2)m-, -N=CH-, -CH=N-, or -(C1-6 alkyl)C=N-; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group -C(=O)N(R5)R6 or group -C(=O)OR7, R8 is absent or represents a bond, an oxygen atom, a sulfur atom, -SO2-, -SO-, -CH2-CH2-, or - CH=CH-, and R9 and R10 represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents - (CH2)n-, -O-(CH2)i-, or -C(=O)NH-(CH2)i-.