301684-75-3

Basic information

• Product Name: (2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoic acid
• Synonyms: (2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoic acid
• CAS NO: 301684-75-3
• Molecular Weight: 305.374
• Mol File: 301684-75-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoic acid(301684-75-3)
• EPA Substance Registry System: (2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoic acid(301684-75-3)

Safety Data

• Hazardous Substances Data: 301684-75-3(Hazardous Substances Data)

Upstream product

• 301684-95-7 (2R)-3-cyclopentyl-2-({[(phenylmethyl)oxy]amino}methyl)propanoic acid 
• 2258-42-6 formyl acetic anhydride 
• 301685-08-5 (4S)-3-[(2R)-3-cyclopentyl-2-(hydroxymethyl)propanoyl]-4-(phenylmethyl)-1,3-oxazolidin-2-one 
• 1152109-83-5 (4S)-3-((2R)-3-cyclopentyl-2-{[(phenylmethyl)oxy]methyl}propanoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one 
• 104-97-2 cyclopentanepropanoyl chloride 
• 301685-11-0 (3R)-3-(cyclopentylmethyl)-1-[(phenylmethyl)oxy]-2-azetidinone 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 301685-10-9 (2R)-3-cyclopentyl-2-(hydroxymethyl)-N-[(phenylmethyl)oxy]propanamide 
• 301685-09-6 (2R)-3-cyclopentyl-2-(hydroxymethyl)propanoic acid 
• 64-18-6 formic acid 

Downstream Products

• 1152109-84-6 (2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoic acid diisopropylethylamine salt 
• 1152110-13-8 ((2R)-3-(2-(2-chloro-5-fluoro-6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-yl)-4-pyrimidinyl)hydrazino)-2-cyclopentylmethyl-3-oxopropyl)(phenylmethoxy)forrmamide 
• 1152110-16-1 ((2R)-3-(2-(6-(1-azetidinyl)-5-fluoro-2-methyl-4-pyrimidinyl)hydrazino)-2-cyclopentylmethyl-3-oxopropyl)(phenylmethoxy)forrmamide 
• 1152110-22-9 ((2R)-2-cyclopentylmethyl-3-(2-(2-ethyl-5-fluoro-6-(4-methyl-1-piperazinyl)-4-pyrimidinyl)hydrazino)-3-oxopropyl)(phenylmethoxy)forrmamide 
• 1152110-45-6 ((2R)-2-cyclopentylmethyl-3-(2-(6-((3S)-3,4-dimethyl-1-piperazinyl)-5-fluoro-2-methyl-4-pyrimidinyl)hydrazino)-3-oxopropyl)(phenylmethoxy)forrmamide 
• 1152110-48-9 ((2R)-2-cyclopentylmethyl-3-(2-(6-((3R)-3,4-dimethyl-1-piperazinyl)-5-fluoro-2-methyl-4-pyrimidinyl)hydrazino)-3-oxopropyl)(phenylmethoxy)forrmamide 
• 1152110-53-6 ((2R)-2-cyclopentylmethyl-3-(2-(5-fluoro-2-methyl-6-((2-pyridinylmethyl)amino)-4-pyrimidinyl)hydrazino)-3-oxopropyl)(phenylmethoxy)forrmamide 
• 1152110-60-5 ((2R)-2-cyclopentylmethyl-3-(2-(6-((2S)-2,4-dimethyl-1-piperazinyl)-5-fluoro-2-methyl-4-pyrimidinyl)hydrazino)-3-oxopropyl)(phenylmethoxy)forrmamide 
• 1152110-74-1 ((2R)-3-cyclopentylmethyl-3-(2-(5-fluoro-6-((4S)-4-hydroxy-3,3-dimethyl-1-pyrrolidinyl)-2-methyl-4-pyrimidinyl)hydrazino)-3-oxopropyl)(phenylmethoxy)forrmamide 
• 1152110-96-7 ((2R)-2-cyclopentylmethyl-3-(2-(6-(4-dimethylamino-3,3-dimethyl-1-pyrrolidinyl)-5-fluoro-2-methyl-4-pyrimidinyl)hydrazino)-3-oxopropyl)(phenylmethoxy)formamide 
• 1152111-02-8 ((2R)-2-cyclopentylmethyl-3-(2-(6-(7-dimethylamino-5-azaspiro[2.4]hept-5-yl)-2-ethyl-5-fluoro-4-pyrimidinyl)hydrazino)-3-oxopropyl)(phenylmethoxy)formamide 
• 1152111-13-1 ((2R)-3-(2-(2-chloro-5-fluoro-6-(3-hydroxy-3-methyl-1-pyrrolidinyl)-4-pyrimidinyl)hydrazino)-2-cyclopentylmethyl-3-oxopropyl)(phenylmethoxy)formamide 
• 1152111-31-3 ((2R)-3-(2-(2-chloro-6-(3-dimethylamino-2,2-dimethyl-1-pyrrolidinyl)-5-fluoro-4-pyrimidinyl)hydrazino)-2-cyclopentylmethyl-3-oxopropyl)(phenylmethoxy)formamide 
• 1152110-01-4 ((2R)-2-cyclopentylmethyl-3-(2-(5-fluoro-2-methyl-6-(1-pyrrolidinyl)-4-pyrimidinyl)hydrazino)-3-oxopropyl)(phenylmethoxy)forrmamide 

Relevant articles and documents

PEPTIDE DEFORMYLASE INHIBITORS

The present invention relates to {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3- oxopropyl}hydroxyformamide compounds of Formula (I): or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity and in treatment methods for bacterial infections

PEPTIDE DEFORMYLASE INHIBITORS

The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I), wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.

PEPTIDE DEFORMYLASE INHIBITORS

Novel PDF inhibitors of Formula (I), pharmaceutical compositions thereof and their use in treating bacterial infections are described.