30169-43-8Relevant academic research and scientific papers
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β-Hydroxyketones
Hilker, Simon,Posevins, Daniels,Unelius, C. Rikard,B?ckvall, Jan-E.
, p. 15623 - 15627 (2021/10/07)
Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α-substituted β-hydroxyketones (β-HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α-substituted β-oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios.
A convenient method for selective C-alkylation of 2-methyl-1,3-diketones
Bedekar,Watanabe,Tanaka,Fuji
, p. 1069 - 1070 (2007/10/02)
A simple and efficient C-alkylation of 2-methyl-1,3-diketones using a combination of lithium iodide and DBU has been developed.
Reactions of copper(II) β-diketonates under free radical conditions. Preparation of highly congested β-diketones
Lloris, Maria E.,Galvez, Nicanor,Marquet, Jorge,Moreno-Manas, Marcial
, p. 8031 - 8042 (2007/10/02)
Copper(II) β-diketonates react with alkyl bromides under free radical conditions to give highly congested β-diketones such as 3-(1-adamantyl)-3-alkylpentane-2,4-diones. Another typical free radical reagent: benzoyl peroxide, reacts also functionalizing the intercarbonyl positions.
