301822-81-1

Basic information

• Product Name: N-(3-methylphenyl)-1-naphthamide
• Synonyms: N-(3-methylphenyl)-1-naphthamide
• CAS NO: 301822-81-1
• Molecular Formula: C₁₈H₁₅NO
• Molecular Weight: 261.3178
• Mol File: 301822-81-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-methylphenyl)-1-naphthamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methylphenyl)-1-naphthamide(301822-81-1)
• EPA Substance Registry System: N-(3-methylphenyl)-1-naphthamide(301822-81-1)

Safety Data

• Hazardous Substances Data: 301822-81-1(Hazardous Substances Data)

Upstream product

• 85-47-2 1-naphthalenesulfonic acid 
• 638-03-9 m-toluidine hydrochloride 
• 68-12-2 N,N-dimethyl-formamide 
• 86-55-5 1-naphthalenecarboxylic acid 
• 108-44-1 1-amino-3-methylbenzene 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 201230-82-2 carbon monoxide 
• 90-14-2 1-Iodonaphthalene 

Relevant articles and documents

Palladium-Catalyzed Annulation of Arylbenzamides with Diaryliodonium Salts

By using diaryliodonium salts, a cylization has been accomplished in the synthesis of N-aryl phenanthridinone derivatives via a cascade of ortho-arylation and Csp2-N bond formation in the presence of palladium catalyst. The reaction exhibits a broad compatibility of readily available N-arylnaphthamides. (Figure presented.).

Preparation and biological properties of ring-substituted naphthalene-1-carboxanilides

In this study, a series of twenty- Two ring-substituted naphthalene-1- carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized carboxanilides was performed against Mycobacterium avium subsp. paratuberculosis. N-(2-Methoxyphenyl)naphthalene-1-carboxamide, N-(3-methoxyphenyl) naphthalene-1-carboxamide, N-(3-methylphenyl)naphthalene-1- carboxamide, N-(4-methylphenyl)naphthalene-1-carboxamide and N-(3-fluorophenyl)naphthalene-1- carboxamide showed against M. avium subsp. paratuberculosis two-fold higher activity than rifampicin and three-fold higher activity than ciprofloxacin. The most effective antimycobacterial compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. The testing of biological activity of the compounds was completed with the study of photosynthetic electron transport (PET) inhibition in isolated spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity expressed by IC50 value of the most active compound N-[4-(trifluoromethyl)phenyl]naphthalene-1- carboxamide was 59 μmol/L. The structure- Activity relationships are discussed.