301847-57-4

Upstream product

• 88-15-3 2-Acetylthiophene 
• 100-52-7 benzaldehyde 
• 82127-11-5 4-phenyl-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 3988-77-0 3-phenyl-1-thiophen-2-yl-propenone 
• 301847-02-9 ethyl 3-amino-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxylate 

Downstream Products

• 847976-72-1 2-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridin-3-one 
• 723745-77-5 3-amino-2-methyl-9-phenyl-7-(2-thienyl)pyrido[3',2':4,5]-thieno[3,2-d]pyrimidine-4(3H)-one 
• 847976-71-0 4-Phenyl-2-[1-phenyl-meth-(E)-ylidene]-6-thiophen-2-yl-thieno[2,3-b]pyridin-3-one 
• 847976-70-9 4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridine-3(2H)-one 
• 443904-61-8 2-methyl-9-phenyl-7-(2-thienyl)pyrido[3',2':4,5]-thieno[3,2-d]oxazine-4-one 

Relevant academic research and scientific papers

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair

The enzyme 15-prostaglandin dehydrogenase (15-PGDH) catalyzes the first step in the degradation of prostaglandins including PGE2. It is a negative regulator of tissue repair and regeneration in multiple organs. Accordingly, inhibitors of 15-PGDH are anticipated to elevate in vivo levels of PGE2 and to promote healing and tissue regeneration. The small molecule SW033291 (1) inhibits 15-PGDH with Ki = 0.1 nM in vitro, doubles PGE2 levels in vivo, and shows efficacy in mouse models of recovery from bone marrow transplantation, ulcerative colitis, and partial hepatectomy. Here we describe optimized variants of 1 with improved solubility, druglike properties, and in vivo activity.

COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.

Synthesis and reactions of some new heterocyclic compounds containing the thienylthieno[2,3-b]pyridine moiety

(4-Aryl-3-cyano-6-(2-thienyl)pyridin-2-ylthio)acethydrazides (5a-c), 3-amino-4-aryl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carbohydrazides (6a-c) and 3-amino-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylic acid (30) were prepared and employed as key intermediates in the synthesis of the title compounds.