30186-39-1

Usage

Physical appearance

Yellowish-orange solid The compound appears as a yellowish-orange solid substance.

Strong, distinct odor

1-PHENYL-1H-PYRROLE-2-CARBALDEHYDE has a noticeable and intense smell.

Use as an intermediate

Synthesis of pharmaceuticals and other organic compounds The compound is commonly used as an intermediate in the production of various pharmaceuticals and other organic compounds.

Use as a flavoring agent

Flavoring purposes It is also utilized as a flavoring agent in food products.

Use in fragrance production

Production of fragrances 1-PHENYL-1H-PYRROLE-2-CARBALDEHYDE is employed in the creation of fragrances due to its unique odor.

Chemical classification

Aldehyde The compound is classified as an aldehyde, which is a type of organic compound containing a carbonyl group (C=O) bonded to a hydrogen atom.

Reactivity

Ability to undergo various chemical reactions 1-PHENYL-1H-PYRROLE-2-CARBALDEHYDE is known for its reactivity and can participate in a wide range of chemical reactions.

Potential health hazards

Caution required for handling Due to its potential health risks, it is important to handle 1-PHENYL-1H-PYRROLE-2-CARBALDEHYDE with care.

Flammability

Fire risk The compound is flammable, which presents an additional safety concern when handling and storing it.

InChI:InChI=1/C11H9NO/c13-9-11-7-4-8-12(11)10-5-2-1-3-6-10/h1-9H

Upstream product

• 20432-40-0 (E)-penta-2,4-dienal 
• 586-96-9 Nitrosobenzene 
• 635-90-5 1-phenylpyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 1003-29-8 2-pyrrole aldehyde 
• 591-50-4 iodobenzene 
• 4497-57-8 2,2,4-trimethyl-3,4-dihydroquinoline-1(2H)-carbaldehyde 
• 2700-30-3 N,N-diisorpopylformamide 
• 607-00-1 diphenylformamide 
• 52008-97-6 N-isopropyl-N-phenylformamide 
• 93-61-8 N-methyl-N-phenylformamide 
• 62-53-3 aniline 
• 67-68-5 dimethyl sulfoxide 
• 59906-91-1 2,5-dihydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal 

Downstream Products

• 74304-92-0 1-phenyl-2-vinylpyrrole 
• 118896-46-1 1-phenyl-2-<(3-pyridinyl)methyl>pyrrole 
• 120777-22-2 1-phenyl-1H-pyrrole-3-carbaldehyde 
• 174415-44-2 (E)-2-nitro-1-(N-phenylpyrrol-2-yl)prop-2-ene 
• 174415-38-4 ethyl 3-(N-phenylpyrrol-2-yl)-4,5-dihydro-1H-pyrroline-2,4-dicarboxylate 
• 174415-35-1 ethyl (E)-3-(N-phenylpyrrol-2-yl)prop-2-enecarboxaldehyde 
• 604809-97-4 ethyl (2Z)-2-methyl-3-[1-phenylpyrrol-2-yl]prop-2-enoate 
• 1161408-51-0 3-(2-(N-methylamino)phenyl)-6-(1-phenyl-pyrrol-2-yl)-5,6-dihydro-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-50-9 3-(4-(N,N-dimethylamino)phenyl)-6-(1-phenyl-pyrrol-2-yl)-5,6-dihydro-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-53-2 3-(naphthalen-1-yl-methyl)-6-(1-phenyl-pyrrol-2-yl)-5,6-dihydro-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 234-95-7 pyrrolo[1,2-a]quinoxaline 
• 74809-37-3 dimethyl 1-phenyl-6,7-dihydroindole-4,5-dicarboxylate 
• 74809-39-5 dimethyl 1-phenylindole-4,5-dicarboxylate 

Relevant academic research and scientific papers

Propionic Acid Derivatives and Methods of Use Thereof

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Hoveyda-Grubbs catalyst analogues bearing the derivatives of: N -phenylpyrrol in the carbene ligand-structure, stability, activity and unique ruthenium-phenyl interactions

We have synthesized a series of N-phenylpyrrole and N-phenylindole carbenes and used them as ruthenium-ligating moieties in the synthesis of Hoveyda-Grubbs catalyst derivatives. We show that most of these complexes are difficult to synthesize and unstable apart from the N-phenylpyrrole-2,6-diisopropylphenyl ruthenium complex and its perbrominated derivative. These two systems are almost completely inactive in ring-closing metathesis at room temperature and become active only at 80 °C. DFT, SAPT0 and DLPNO-CCSD(T) calculations suggest that the rarely occurring phenyl-ruthenium interactions are responsible for the very slow initiation of these precatalysts at low temperatures.

Selective and Efficient Formylation of Indoles (C3) and Pyrroles (C2) Using 2,4,6-Trichloro-1,3,5-Triazine/Dimethylformamide (TCT/DMF) Mixed Reagent

This study introduces an efficient method for the selective formylation of indoles and pyrroles at the positions of C(3) and C(2), respectively. The mixture of three equivalents of N,N-dimethylformamide and one equivalent of 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride) generates an easy handling formylating agent for the efficient formylation of these classes of compounds to give the corresponding aldehydes under mild reaction conditions. This procedure was highly efficient, and a range of formylated indoles and pyrroles were obtained in good to excellent yields.

Copper-catalyzed aerobic methyl/methylene oxygenation and C-H formylation with a DABCO-DMSO system for the synthesis of carbonyl indoles and pyrroles

Copper-catalyzed aerobic methyl/methylene oxygenation of substituted indoles and pyrroles was developed using 1,4-diazabicyclo[2.2.2]octane (DABCO) as an additive in dimethyl sulfoxide (DMSO). Similar aerobic catalytic conditions could also be utilized for direct C-H formylation of C(3) on indoles and C(2) on pyrroles.

Direct and efficient synthesis of pyrrole-3-carbaldehydes by Vilsmeier-Haack formylation of pyrroles with sterically crowded amides

A simple and convenient synthetic method to prepare N-substituted pyrrole-3-carbaldehydes by Vilsmeier-Haack formylation of pyrroles using sterically crowded formamides was developed. The dependence of the formylation regioselectivity on steric features of substrates and reagents is discussed. Georg Thieme Verlag Stuttgart · New York.

Enantioselective addition of diethylzinc to aldehydes catalyzed by β-amino alcohols derived from (1R,2S)-norephedrine

β-Amino alcohols derived from (1R,2S)-norephedrine were synthesized and used as ligands in the catalytic enantioselective diethylzinc addition to benzaldehydes. N-alkylated (1R,2S)-norephedrine-based derivative 3a gave the highest enantioselectivity. The effects of different parameters on the enantioselectivity of the product were investigated. Copyright

PYRROLE ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

Polycyclic fused heteroring compounds metal complexes and polymerization process

Metal complexes comprising a polycyclic, heteroatom containing fused ring compound comprising at least a cyclopentadienyl ring having fused thereto a 5-membered polyatomic ring containing one or more ring atoms selected from groups 15 or 16 of the Periodic Table of the Elements and lacking substituents forming 6-membered, aromatic fused rings; polymerization catalysts; and olefin polymerization processes using the same are disclosed.

Asymmetric biocatalytic hydrocyanation of pyrrole carboxaldehydes

The asymmetric hydrocyanation of pyrrole-2- and -3-carboxaldehydes substituted with either methyl, benzyl or phenyl in the 1-position catalyzed by the hydroxynitrile lyases from Hevea brasiliensis (HbHNL) and Prunus amygdalus (PaHNL) is reported. The products could be isolated - after O-silylation - with moderate to good enantiomeric purity although the carbonyl activity of the substrates was found to be very low, which is supported by quantum-chemical calculations. Structural effects concerning substrate size and regiochemistry are discussed considering docking calculations based on the X-ray crystal structures of the two enzymes. From these calculations one particular amino acid residue (Trp-128) in the active site of HbHNL could be identified, which plays a major role for the appropriate binding of structurally demanding carbonyl compounds.

Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles

This paper details the copper-catalyzed N-arylation of π-excessive nitrogen heterocycles. The coupling of either aryl iodides or aryl bromides with common nitrogen heterocycles (pyrroles, pyrazoles, indazoles, imidazoles, and triazoles) was successfully performed in good yield with catalysts derived from diamine ligands and CuI. General conditions were found that tolerate functional groups such as aldehydes, ketones, alcohols, primary amines, and nitriles on the aryl halide or heterocycle. Hindered aryl halides or heterocycles were also found to be suitable substrates using the conditions reported herein.