30189-12-9Relevant academic research and scientific papers
Conversion of 1,3-Dimethyl-5-(Arylazo)-6-Amino-Uracils to 1,3-Dimethyl-5-(Arylazo)-Barbituric Acids: Spectroscopic Characterization, Photophysical Property and Determination of pKa of the Products
Debnath, Diptanu,Purkayastha, Atanu,Choudhury, Rupasree,Misra, Tarun Kumar
, p. 580 - 589 (2016/07/26)
The study of inter-conversion between molecules, especially biologically and pharmaceutically important molecules, is extremely important. This study reports the inter-conversion between two azo-derivtives: azo-6-aminouracils to azo-barbituric acids. We s
Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors
Xue, Mengzhu,Xu, Minghao,Lu, Weiqiang,Huang, Jin,Li, Honglin,Xu, Yufang,Liu, Xiaofeng,Zhao, Zhenjiang
, p. 747 - 752 (2013/07/26)
The 90 kDa ribosomal S6 kinases (RSKs), especially RSK2, have attracted attention for the development of new anticancer agents. Through structural optimization of the hit compound 1 from our previous study, a series of barbituric acid aryl hydrazone analogues were designed and synthesized as potential RSK2 inhibitors. The most potent one, compound 9, showed a higher activity against RSK2 with an IC50 value of 1.95 μM. To analyze and elucidate their structure-activity relationship, the homology model of RSK2 N-terminal kinase domain was built and molecular docking simulations were performed, which provide helpful clues to design new inhibitors with desired activities.
