30198-01-7

Basic information

• Product Name: 2-HYDROXY-4-METHYL-8-METHOXYQUINOLINE
• Synonyms: 2-HYDROXY-4-METHYL-8-METHOXYQUINOLINE;AKOS BC-1762;8-Methoxy-4-methyl-1H-quinolin-2-one
• CAS NO: 30198-01-7
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.21
• Mol File: 30198-01-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 220-225 °C
• Boiling Point: 387.6°Cat760mmHg
• Flash Point: 188.2°C
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 3.26E-06mmHg at 25°C
• Refractive Index: 1.557
• PKA: 11.10±0.70(Predicted)
• CAS DataBase Reference: 2-HYDROXY-4-METHYL-8-METHOXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-METHYL-8-METHOXYQUINOLINE(30198-01-7)
• EPA Substance Registry System: 2-HYDROXY-4-METHYL-8-METHOXYQUINOLINE(30198-01-7)

Safety Data

• Hazardous Substances Data: 30198-01-7(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-4-METHYL-8-METHOXYQUINOLINE is a chemical compound with a molecular formula C12H11NO2. It is a derivative of quinoline, a heterocyclic aromatic compound. This chemical is known for its wide range of biological activities, including antimicrobial, antimalarial, and antitumor properties. It is also used in the synthesis of various pharmaceuticals and organic compounds. 2-HYDROXY-4-METHYL-8-METHOXYQUINOLINE has been studied for its potential applications in drug development and medical research.

InChI:InChI=1/C11H11NO2/c1-7-6-10(13)12-11-8(7)4-3-5-9(11)14-2/h3-6H,1-2H3,(H,12,13)

Upstream product

• 4341-76-8 Ethyl 2-butynoate 
• 93-26-5 2-methoxyacetanilide 
• 90-04-0 2-methoxy-phenylamine 
• 50553-65-6 8-methoxy-4-methyl-6-nitro-2(1H)-quinolone 
• 141-97-9 ethyl acetoacetate 
• 92-15-9 2'-methoxyacetoacetanilide 
• 110-86-1 pyridine 
• 104995-07-5 8-methoxy-4-methyl-5-amino-2(1H)-quinolone 

Downstream Products

• 50553-65-6 8-methoxy-4-methyl-6-nitro-2(1H)-quinolone 
• 50553-66-7 8-methoxy-4-methyl-5-nitro-2(1H)-quinolone 
• 30198-01-7 2-chloro-8-methoxy-4-methylquinoline 
• 1321948-25-7 8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(phenyl)-1'-azetidinyl]aminoquinoline 
• 1321948-27-9 8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-chloro-phenyl)-1'-azetidinyl]aminoquinoline 
• 1321948-28-0 8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline 
• 1321948-34-8 C₂₀H₁₉N₃O₂S 
• 1321948-36-0 C₂₀H₁₈ClN₃O₂S 
• 1321948-38-2 C₂₀H₁₉N₃O₃S 
• 1321948-17-7 8-methoxy-4-methyl-2-(phenylidenyl-iminoamino)quinoline 
• 1321948-19-9 8-methoxy-4-methyl-2-(o-chlorophenylidenyl-iminoamino)quinoline 
• 878386-84-6 8-methoxy-4-methyl-2-(o-hydroxyphenylidenyl-iminoamino)quinoline 
• 30198-02-8 8-hydroxy-4-methylquinolin-2(1H)-one 
• 61703-95-5 8-methoxy-4-methylquinoline 

Relevant articles and documents

Synthesis and antileishmanial evaluation of thiazole orange analogs

Cyanine compounds have previously shown excellent in vitro and promising in vivo antileishmanial efficacy, but the potential toxicity of these agents is a concern. A series of 22 analogs of thiazole orange ((Z)-1-methyl-4-((3-methylbenzo[d]thiazol-2(3H)-ylidene)methyl)quinolin-1-ium salt), a commercial cyanine dye with antileishmanial activity, were synthesized in an effort to increase the selectivity of such compounds while maintaining efficacy. Cyanines possessing substitutions on the quinolinium ring system displayed potency against Leishmania donovani axenic amastigotes that differed little from the parent compound (IC50 12–42 nM), while ring disjunction analogs were both less potent and less toxic. Changes in DNA melting temperature were modest when synthetic oligonucleotides were incubated with selected analogs (ΔTm ≤ 5 °C), with ring disjunction analogs showing the least effect on this parameter. Despite the high antileishmanial potency of the target compounds, their toxicity and relatively flat SAR suggests that further information regarding the target(s) of these molecules is needed to aid their development as antileishmanials.

NOVEL COMPOUND WITH ANTIBACTERIAL ACTIVITY

A compound represented by the general formula (I) or a salt thereof having a potent antibacterial activity against bacteria that have acquired resistance to quinolones, and a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing the compound or a salt thereof as an active ingredient, as well as a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing a combination of the compound or a salt thereof, and a quinolone.

A study of antibacterial activity of some novel 8-methoxy-4-methyl- quinoline derivatives

In the present study, some quinoline derivatives have been synthesized like8-methoxy-4-methyl-2-amino-(3'-chloro-2'-oxo-4'-substituted aryl-1'-azetidinyl)quinolines 8-12 and 8-methoxy-4-methyl-2-amino-(2'- substituted aryl-4'-oxo-1',3'-thiazolidin-3'-yl)