30213-79-7

Basic information

• Product Name: 3-(4-Nitro-phenyl)-5-methyl-isoxazole
• Synonyms: 3-(4-Nitro-phenyl)-5-methyl-isoxazole;5-Methyl-3-(4-nitrophenyl)isoxazole
• CAS NO: 30213-79-7
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.18212
• Mol File: 30213-79-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-Nitro-phenyl)-5-methyl-isoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Nitro-phenyl)-5-methyl-isoxazole(30213-79-7)
• EPA Substance Registry System: 3-(4-Nitro-phenyl)-5-methyl-isoxazole(30213-79-7)

Safety Data

• Hazardous Substances Data: 30213-79-7(Hazardous Substances Data)

Upstream product

• 917-54-4 methyllithium 
• 142598-84-3 5-bromo-3-(4-nitrophenyl)isoxazole 
• 1011-84-3 4-nitrobenzohydroximoyl chloride 
• 1287686-47-8 5-(bromomethyl)-3-(4-nitrophenyl)-4,5-dihydroisoxazole 
• 946-49-6 4-(p-nitrophenyl)-3-butene-2-one 
• 1129-37-9 4-nitrobenzaldehyde oxime 
• 833462-36-5 3-(4-nitro-phenyl)-5-phenylselanylmethyl-4,5-dihydro-isoxazole 
• 867203-97-2 3-(4-nitrophenyl)-5-iodomethylisoxazoline 
• 4749-28-4 2-nitropropene 
• 75624-78-1 <3-(4-Nitrophenyl)-5-isoxazolylmethyl>triphenylphosphonium-chlorid 

Downstream Products

• 1175952-06-3 4-(5-methylisoxazol-3-yl)aniline 
• 1287686-96-7 2,6-difluoro-N-(4-(5-methylisoxazol-3-yl)phenylcarbaphenylcarbamoyl)benzamide 

Relevant articles and documents

Preparation method of isoxazole derivative

The invention relates to a preparation method of an isoxazole derivative, which comprises the following steps of mixing an propargyl alcohol derivative, a halogen source, an acid and a solvent, and heating to react; adding the hydroxylamine into the react

Design, synthesis, and insecticidal evaluation of new benzoylureas containing isoxazoline and isoxazole group

Twenty-two new benzoylphenylureas containing isoxazoline and the isoxazole group were designed and synthesized, and their structures were characterized by 1H NMR and elemental analysis (or HRMS). The larvicidal activities against Oriental armyw

Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles

(Figure Presented) A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.

Preparation of isoxazol(in)yl substituted selenides and their further deselenenylation reaction to synthesize 3,5-disubstituted isoxazoles

We report a mild 1,3-dipolar cycloaddition protocol for the preparation of 3-aryl-5-phenylselenomethyl isoxazoles and isoxazolines regioselectively. The former was further reacted with LDA and electrophilic substrates followed by selenoxide syn-eliminatio

Reactivity of p-phenyl substituted β-enamino compounds using k- 10/ultrasound. II [1]. Synthesis of isoxazoles and 5-isoxazolones

The condensation of 4-phenyl substituted β-enamino ketones 1a-d and β- enamino esters 5a-d with hydroxylamine hydrochloride using K-10 as the solid support under sonication was studied to evaluate the formation of isoxazole and 5-isoxazolone rings from β-enamino compounds with a substituted aromatic ring. Isoxazoles 2a-c, 3c-d and 5-isoxazolones 6a-c and 7a-d were obtained. The use of K-10/ultrasound in this reaction furnished novel results in some cases.

Derivatization of 5-Halogeno-4-(4-nitrophenyl)isoxazoles

Treatment of 5-halogeno-3-(4-nitrophenyl)isoxazoles with various reagents demonstrated competitive substitution between the hydrogens of the arene and the halogens of the isoxazole.When an alkyllithium or Grignard reagents was used, alkylation took place at C-3 of the phenyl ring.For alkyl amines and alkoxides as reagents, these bases underwent substitution of halide.Weaker bases (aromatic amines) were observed to be inert towards the title compounds.

Reactions with Organophosphorus Compounds, XLVI. Reactivity Umpolung of 1,3-Dioxo Compounds through Introduction of a Triphenylphosphonio Group. - Regioselective Syntheses of Isoxazoles and Pyrazoles from (2,4-Dioxoalkyl)triphenylphosphonium Salts

Phosphonium salts 2 and 6, upon deprotonation with BuLi and subsequent reaction with acyl halides, yield the γ-acyl derivatives 3 and 7, respectively, which on treatment with hydrochloric acid afford the corresponding (dioxoalkyl)phosphonium salts 4 and 8.Isoxazole derivatives 9 and 10 are formed regioselectivly from 4 and 8 with NH2OH*HCl, while with R-NH-NH2*HCl (R = H or C6H5) the pyrazole-containing phosphonium salts 14 and 15 are obtained in an analogous reaction.In each case the direction of cyclisation is different to the reactions of the corresponding non-phosphorus substituted 1,3-dioxo compounds.On treatment with aqueous NaOH 9 and 10 are cleaved to triphenylphosphane oxide and isoxazoles 11 and 12, while 14 and 15 yield the pyrazoles 16 and 17.Wittig reaction of 9a or 14a with aldehydes or ketones leads to the isoxazole olefins 13 or the pyrazole olefins 18, respectively.