30219-15-9

Basic information

• Product Name: bufotalin 3-hemisuberate
• Synonyms: bufotalin 3-hemisuberate
• CAS NO: 30219-15-9
• Molecular Weight: 600.75
• Mol File: 30219-15-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: bufotalin 3-hemisuberate(CAS DataBase Reference)
• NIST Chemistry Reference: bufotalin 3-hemisuberate(30219-15-9)
• EPA Substance Registry System: bufotalin 3-hemisuberate(30219-15-9)

Safety Data

• Hazardous Substances Data: 30219-15-9(Hazardous Substances Data)

Upstream product

• 571-31-3 Epietiocholanolone 

Downstream Products

• 61507-75-3 butofalin 3-hemisuberate p-nitrophenyl ester 

Relevant articles and documents

Unified Total Synthesis of Five Bufadienolides

We report a unified total synthesis of five bufadienolides: bufalin (1), bufogenin B (2), bufotalin (3), vulgarobufotoxin (4), and 3-(N-succinyl argininyl) bufotalin (5). After the steroidal ABCD ring 8 was produced, the D ring was cross-coupled with a 2-pyrone moiety and stereoselectively epoxidized to generate 6. TMSOTf promoted a stereospecific 1,2-hydride shift from 6 to establish the β-oriented 2-pyrone of 19. Functional group manipulations from 19 furnished 1-5, which potently inhibited cancer cell growth.