30220-22-5Relevant academic research and scientific papers
Synthesis of O -Aroyl- N, N -dimethylhydroxylamines through Hypervalent Iodine-Mediated Amination of Carboxylic Acids with N, N -Dimethylformamide
Zhang, Chuancheng,Yue, Qiang,Xiao, Zhen,Wang, Xianglan,Zhang, Qian,Li, Dong
, p. 4303 - 4308 (2017)
An efficient protocol for the synthesis of O -aroyl- N, N -dimethylhydroxylamines, which are important electrophilic amination reagents, is described. The reaction between carboxylic acids and N, N -dimethylformamide is mediated by hypervalent iodine and
4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS
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Page/Page column 61, (2010/04/06)
4-aryloxyquinolin-2(1H)-ones as mtor kinase and PI3 kinase inhibitors, for use as anti-cancer agents. Compounds of the formula I and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, R3, R4, R5, R6, and R7 are defined as set forth herein are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier, methods of making the compounds of the invention and methods of using the compounds for inhibiting mTOR and PI3 kinases and for treating cancers.
