30225-97-9

Upstream product

• 30225-96-8 1-(2-hydroxy-3,4,5-trimethoxyphenyl)ethan-1-one 
• 77-78-1 dimethyl sulfate 
• 69616-56-4 2',5'-dihydroxy-3',4'-dimethoxyacetophenone 
• 74-88-4 methyl iodide 
• 5396-18-9 2'-hydroxy-3',4'-dimethoxyacetophenone 
• 19676-64-3 2,3,4-trimethoxyphenol 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 
• 30225-80-0 2,3,4-trimethoxyphenyl acetate 
• 30225-82-2 2,3,4-trimethoxyphenyl formate 
• 13909-73-4 2',3',4'-trimethoxyacetophenone 
• 3997-18-0 2-hydroxy-3,4-dimethoxyphenol 
• 21450-56-6 1,2,3,4-tetramethoxybenzene 
• 87402-96-8 2',3',4',5,5',6,7,8,-octamethoxyflavone 
• 87402-97-9 2',3',4',5,5',6,7-heptamethoxyflavone 

Downstream Products

• 93394-48-0 1-(2'-methyloxiranyl)-2,3,4,5-tetramethoxybenzene 
• 30225-99-1 2,3,4,5-Tetramethoxyphenol 
• 67231-43-0 2,3,4,5-Tetramethoxybenzoylaceton 
• 30225-98-0 2,3,4,5-Tetramethoxy-acetoxybenzol 

Relevant academic research and scientific papers

Nobiletin derivative or pharmaceutically acceptable salt thereof as well as preparation method and application thereof

The invention discloses a nobiletin derivative or a pharmaceutically acceptable salt thereof as well as a preparation method and application thereof. The nobiletin derivative has a structural formula(I) shown in the description, in the formula, R1, R2, R3 and R4 are respectively selected from hydrogen, halogen, hydroxyl, amino, C1-6 substituted or non-substituted alkoxy, a C1-6 substituted or non-substituted ester group, C1-6 substituted or non-substituted alkamino and a C1-6 substituted or non-substituted amide group; R5 is selected from a C3-9 substituted or non-substituted aromatic ring and a C3-9 substituted or non-substituted aromatic heterocyclic ring; and X is selected from O or NR6. The nobiletin derivative or the pharmaceutically acceptable salt thereof, which is disclosed by theinvention, is novel in structure, and in addition, the compound has an excellent inhibition function on P-gp, can be prepared into a P-gp inhibitor, is capable of treating and/or preventing related diseases caused by P-gp, particularly diseases related to tumor drug resistance, or can be mixed and used with other medicines and used as a drug resistance reversal agent, has a high reversion multiple, and is capable of remarkably improving medicine effects of medicines.

Synthesis of (2'-Methyloxiranyl)quinones as Bioreductive Alkylating Agents

1,4-Benzoquinones and 1,4-naphthoquinones bearing 2'-methyloxiranyl substituents have been synthesized as new bioreductive alkylating agents.The method presented here involved the synthesis of 2-acetyl-1,4-dimethoxybenzenes 6a, b, d and -naphthalenes 6c,

TWO POLYMETHOXYFLAVONES FROM AGERATUM HOUSTONIANUM

Besides agecorynin C, eupalestin and lucidin dimethyl ether, two new highly oxygenated flavones were isolated from Ageratum houstonianum.Their structures were established by spectroscopic and degradative evidence as 5,6,7,8,2',3',4',5'-octamethoxyflavone and 5,6,7,2',3',4',5'-heptamethoxyflavone. - Key Word Index: Ageratum houstonianum; Asteraceae; Eupatorieae; new octasubstituted and heptasubstituted flavones.