30226-16-5

Usage

Uses

Used in Organic Synthesis:
Acetic acid, 2-(1H-indazol-5-yloxy)is used as a building block in organic synthesis for the creation of various chemical compounds. The 2-(1H-indazol-5-yloxy) group attached to the acetic acid molecule provides specific chemical reactivity, making it a valuable tool in the synthesis of new compounds.
Used in Pharmaceutical Research and Development:
Acetic acid, 2-(1H-indazol-5-yloxy)is used in pharmaceutical research and development for drug discovery. The 2-(1H-indazol-5-yloxy) group may impart certain biological activities to the acetic acid molecule, making it a promising candidate for the development of new drugs and therapeutic agents.
Used in Chemical Processes:
Acetic acid, 2-(1H-indazol-5-yloxy)is used in various chemical processes due to its versatility and potential applications in different fields of science and industry. Acetic acid, 2-(1H-indazol-5-yloxy)-'s unique structure and properties make it a valuable tool for researchers and scientists working in a wide range of disciplines.

InChI:InChI=1/C9H8N2O3/c12-9(13)5-14-7-1-2-8-6(3-7)4-10-11-8/h1-4H,5H2,(H,10,11)(H,12,13)

Upstream product

• 15579-15-4 5-hydroxy-1H-indazole 
• 105-36-2 ethyl bromoacetate 

Relevant academic research and scientific papers

SELECTIVE NON-CYCLIC NUCLEOTIDE ACTIVATORS FOR THE CAMP SENSOR EPAC1

The invention relates generally to novel EPAC1 activators, such as Formula (I) and (II) and the preparation thereof as well as the use of EPAC1 activators disclosed herein as to selectively activate EPAC1 in cells.

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Exchange proteins directly activated by cAMP (EPAC) play a central role in various biological functions, and activation of the EPAC1 protein has shown potential benefits for the treatment of various human diseases. Herein, we report the synthesis and biochemical evaluation of a series of noncyclic nucleotide EPAC1 activators. Several potent EPAC1 binders were identified including 25g, 25q, 25n, 25u, 25e, and 25f, which promote EPAC1 guanine nucleotide exchange factor activity in vitro. These agonists can also activate EPAC1 protein in cells, where they exhibit excellent selectivity toward EPAC over protein kinase A and G protein-coupled receptors. Moreover, 25e, 25f, 25n, and 25u exhibited improved selectivity toward activation of EPAC1 over EPAC2 in cells. Of these, 25u was found to robustly inhibit IL-6-activated signal transducer and activator of transcription 3 (STAT3) and subsequent induction of the pro-inflammatory vascular cell adhesion molecule 1 (VCAM1) cell-adhesion protein. These novel EPAC1 activators may therefore act as useful pharmacological tools for elucidation of EPAC function and promising drug leads for the treatment of relevant human diseases.