302344-63-4

Usage

Structure

Contains an amino group, a carbonitrile group, a chromene ring system, a methoxyphenyl group, and multiple methyl groups

Potential applications

Medicinal chemistry, drug development

Unique structural features

Presence of functional groups that can be modified for creating new compounds with biological activity
Interesting target for further research and study in various fields

Upstream product

• 2972-72-7 2-(3-methoxybenzylidene)malononitrile 
• 126-81-8 dimedone 
• 591-31-1 3-methoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 100-83-4 meta-hydroxybenzaldehyde 

Relevant academic research and scientific papers

An eco-friendly innovative halide and metal-free basic ionic liquid catalyzed synthesis of tetrahydrobenzo [b] pyran derivatives in aqueous media: A sustainable protocol

A novel imidazolium-based highly efficient, recoverable, and reusable basic ionic liquid [PEMIM][OH] was synthesized using a very simple approach. This ionic liquid was employed as a catalyst for the multicomponent synthesis of tetrahydrobenzo[b]pyran der

Introducing rGO@Fe3O4@Ni as an efficient magnetic nanocatalyst for the synthesis of tetrahydrobenzopyranes via multicomponent coupling reactions of dimedone, malononitrile, and aromatic aldehydes

In this study, the synthesis and characterization of the modified GO and rGO@Fe3O4@Ni composite systems were investigated. Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron mic

Introduction of succinimide as a green and sustainable organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b] pyran derivatives

Aim and Objective: In this work, we tried to introduce a non-toxic and stable organic compound named succinimide as a green and efficient organo-catalyst for the promotion of the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives

Tungsten oxides: green and sustainable heterogeneous nanocatalysts for the synthesis of bioactive heterocyclic compounds

Tungsten oxide (WO3) as an efficient heterogeneous catalyst was preparedviaa simple hydrothermal route for the synthesis of a wide range of bioactive heterocyclic compounds. The present investigation deals with the rapid and low-cost synthesis

Introduction of bis-imidazolium dihydrogen phosphate as a new green acidic ionic liquid catalyst in the synthesis of arylidene malononitrile, ethyl (E)-3-(aryl)-2-cyanoacrylate and tetrahydrobenzo[b]pyran derivatives

In this work, [H2-Bisim][H2PO4]2 as a novel bis-imidazole-based acidic ionic liquid has been synthesized and characterized with a variety of techniques including FT-IR, 1H, 13C, 31/su

Mechanical ball milling auxiliary synthesis method 2 -amino -3 - cyano - 4H - pyran compound

The invention relates to the technical field of chemical synthesis, and aims to solve the problems that 2 - amino -3 - cyano - 4H - pyran compounds are large in pollution and tedious in preparation in the prior art, and discloses a mechanical ball milling auxiliary synthesis method 2 -amino -3 - cyano - 4H - pyran compound which comprises the following steps: (a) the substrate 1. The substrate 2 and malononitrile were subjected to mechanical ball milling after addition of a protein catalyst and a grinding aid as a raw material. (b) Ball milling, the reactants are scraped off, the solvent is added, and the solvent is added, and after filtration, 2 - amino -3 - cyano - 4H - pyran compounds are prepared by column chromatography. The mechanical ball milling technology facilitates mutual contact of reactant molecules, realizes no solvent reaction, and is easily available to the environment. The method effectively realizes the green synthesis of 2 - amino -3 - cyano - 4H - pyran compounds, and is mild in preparation conditions, simple and convenient to operate and high in reaction rate.

One-pot synthesis of 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles using sodium citrate as an organo-salt based catalyst in aqueous ethanol

Sodium citrate as a highly efficient catalyst is developed for the synthesis of functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles. This method involves a one-pot three-component reaction of aromatic aldehydes, malononitrile and 1,3

Magnetized melamine-modified polyacrylonitrile (PAN@melamine/Fe3O4) organometallic nanomaterial: Preparation, characterization, and application as a multifunctional catalyst in the synthesis of bioactive dihydropyrano [2,3-c]pyrazole

An efficient magnetic polymer-based nanomaterial was prepared in three main steps including synthesis of polyacrylonitrile (PAN), modification of PAN with melamine, and magnetization of the PAN@melamine compound by in situ construction of Fe3O

Ionic liquids containing plant derived benzoate as anions, exhibiting supramolecular polymeric aggregation: Impact of the aggregation on organic catalysis in aqueous medium

Naturally occurring benzoic acid (BA) derived anions have been used to prepare halogen free hydrophilic ionic liquids (ILs 1–4). The supramolecular polymeric aggregation behaviour of these ILs has been studied through high-resolution electron spray ioniza

Green protocol for synthesis of MgFe2O4 nanoparticles and study of their activity as an efficient catalyst for the synthesis of chromene and pyran derivatives under ultrasound irradiation

In this study, the MgFe2O4 nanoparticles were synthesized via a green and simple approach. Then an effective procedure to synthesize 2-amino-7-hydroxy-4H-chromene and tetrahydrobenzo[b]pyran derivatives was established through the ch