302351-88-8

Basic information

• Product Name: N-(2-(hex-1-yn-1-yl)phenyl)formamide
• Synonyms: N-(2-(hex-1-yn-1-yl)phenyl)formamide
• CAS NO: 302351-88-8
• Molecular Weight: 201.268
• Mol File: 302351-88-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(2-(hex-1-yn-1-yl)phenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(hex-1-yn-1-yl)phenyl)formamide(302351-88-8)
• EPA Substance Registry System: N-(2-(hex-1-yn-1-yl)phenyl)formamide(302351-88-8)

Safety Data

• Hazardous Substances Data: 302351-88-8(Hazardous Substances Data)

Upstream product

• 10113-39-0 N-formyl-2-iodoaniline 
• 693-02-7 hex-1-yne 
• 615-43-0 2-iodophenylamine 
• 116491-50-0 2-(hex-1-ynyl)aniline 
• 2258-42-6 formyl acetic anhydride 

Downstream Products

• 247222-82-8 2-(1-hexynyl)phenyl isocyanide 

Relevant articles and documents

Alkanethiol-Mediated Cyclization of o-Alkynylisocyanobenzenes: Synthesis of Bis-Thiolated Indole Derivatives

Reactions of o-alkynylisocyanobenzenes with a variety of alkanethiols (Alk-SH) provide the corresponding bis-thiolated indole derivatives. The advantages of the reaction include metal-free, room-temperature, mild reaction conditions and broad functional group compatibility. The reaction proceeds via nucleophilic addition of an alkanethiol to an isonitrile moiety, 5-exo cyclization, followed by nucleophilic addition of an alkanethiol to a 3-alkylidene indole intermediate. Density functional calculations on the electronic structures and relative free energies of 5-exo and 6-endo cyclization pathways support that the 5-exo cyclization is preferable.

Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes

A facile synthesis of various functionalized 3-substituted quinolin-2(1H)-ones through Ag(i) nitrate-catalyzed cyclization of o-alkynylisocyanobenzenes is described. The reaction allows rapid and convenient access to 3-substituted quinolin-2(1H)-one scaffolds in moderate to good yields.

Synthesis of 2-halogenated quinolines by halide-mediated intramolecular cyclization of o-alkynylaryl isocyanides

When o-alkynylaryl isocyanides 1 are treated with triethylamine in chloroform, intramolecular chlorinating cyclization of the isocyanides takes place, affording the corresponding 2-chlorinated quinoline derivatives 2 in good to excellent yields, selective