302355-79-9

Basic information

• Product Name: Morpholine, 4-(3-azetidinyl)- (9CI)
• Synonyms: Morpholine, 4-(3-azetidinyl)- (9CI);4-(3-azetidinyl)morpholine(SALTDATA: 2HCl 0.3H2O);4-(Azetidin-3-yl)morpholine
• CAS NO: 302355-79-9
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.19886
• Product Categories: AMINETERTIARY
• Mol File: 302355-79-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 227℃
• Flash Point: 91℃
• Appearance: /
• Density: 1.100
• Vapor Pressure: 0.079mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: Morpholine, 4-(3-azetidinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-(3-azetidinyl)- (9CI)(302355-79-9)
• EPA Substance Registry System: Morpholine, 4-(3-azetidinyl)- (9CI)(302355-79-9)

Safety Data

• Hazardous Substances Data: 302355-79-9(Hazardous Substances Data)

Usage

General Description

Morpholine, 4-(3-azetidinyl)- (9CI) is a chemical compound that belongs to the group of heterocyclic compounds. It is a five-membered cyclic amine with a morpholine ring structure and a three-carbon azetidine ring. This chemical is used in various industrial applications, such as in the production of pharmaceuticals, agricultural chemicals, and as a solvent in the manufacturing of polymers and resins. It is also used as a corrosion inhibitor in the oil and gas industry and as a stabilizer in the production of rubber and plastics. Additionally, 4-(3-azetidinyl)morpholine has potential applications in organic synthesis and as a building block for the synthesis of other compounds. However, it is important to handle and use this chemical with care, as it can be harmful if not properly managed.

InChI:InChI=1/C7H14N2O/c1-3-10-4-2-9(1)7-5-8-6-7/h7-8H,1-6H2

Upstream product

• 110-91-8 morpholine 
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• 6963-32-2 2,3-dibromopropylamine hydrobromide 
• 55438-65-8 1-Diphenylmethyl-3-morpholinoazetidine 
• 1290136-89-8 tert-butyl 3-morpholinoazetidine-1-carboxylate 

Relevant articles and documents

7-(MORPHOLIN-4-YL)PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL FOR THE TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES OR CANCER

A compound of the general formula (I) wherein Y represents -CH2- or >C=0; R1 is selected from the group consisting of A1, A2 and A3; R2 represents dioxothiomorpholino moiety B1, piperazinyl moiety B2, azetidinyl moiety B3, or piperidinyl moiety B4; R3 is selected from the group consisting of H, halogen, and C1 -C4 alkyl; R4 is selected from the group consisting of C1 -C4 alkyl, C3-C4- cycloalkyl, C1 -C4 alkyl substituted with C1 -C4 alkoxy, and CHF2, and their pharmaceutically acceptable salts. Pharmaceutical compositions comprising said compounds and their use in the treatment of diseases of immune system, inflammatory diseases and cancer.

Treatment of excessive osteolysis with indolinone compounds

Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.

Treatment of acute myeloid leukemia with indolinone compounds

A method of treating acute myeloid leukemia in patient positive for FLT-3-ITD is described. The treatment is accomplished by administration of a compound of Formula I or II as defined herein.