30245-24-0

Usage

Type of compound

Natural chemical compound, coumarins

Sources

Found in many plants, particularly in the genus Artemisia

Properties

+ Antioxidant
+ Anti-inflammatory
+ Anti-fibrotic
+ Anti-coagulant
+ Anti-hypertensive

Potential therapeutic effects

+ Liver fibrosis
+ Cardiovascular disease
+ Cancer

Other uses

Natural food preservative due to antimicrobial properties.

Upstream product

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Relevant academic research and scientific papers

Inhibitory effect of flavonoids on human glutaminyl cyclase

Glutaminyl cyclase (QC) plays an important role in the pathogenesis of Alzheimer's disease (AD) and can be a potential target for the development of novel anti-AD agents. However, the study of QC inhibitors are still less. Here, phenol-4′ (R1-), C5-OH (R2-) and C7-OH (R3-) modified apigenin derivatives were synthesized as a new class of human QC (hQC) inhibitors. The efficacy investigation of these compounds was performed by spectrophotometric assessment and the structure-activity relationship (SAR) was evaluated. Molecular docking was also carried out to analyze the binding mode of the synthesized flavonoid to the active site of hQC.