25015-92-3

Basic information

• Product Name: 2-Chloro-2',4'-dihydroxyacetophenone
• Synonyms: 2-chloro-2-4-dihydroxyacetophenone;2,4-Dihydroxyphenacyl chloride;2-Chloro-1-(2,4-dihydroxyphenyl)ethanone;Ethanone, 2-chloro-1-(2,4-dihydroxyphenyl)-;2-Chloro-2',4'-dihydroxyacetophenone, 2-Chloro-1-(2,4-dihydroxyphenyl)ethan-1-one;2-chloro-1-(2,4-dihydroxyphenyl)ethan-1-one
• CAS NO: 25015-92-3
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.59
• Mol File: 25015-92-3.mol
• Article Data: 37

Chemical Properties

• Melting Point: 130-132 ºC
• Boiling Point: 366.4 °C at 760 mmHg
• Flash Point: 175.4 °C
• Appearance: /
• Density: 1.444
• Vapor Pressure: 6.98E-06mmHg at 25°C
• Refractive Index: 1.611
• PKA: 7.31±0.35(Predicted)
• CAS DataBase Reference: 2-Chloro-2',4'-dihydroxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-2',4'-dihydroxyacetophenone(25015-92-3)
• EPA Substance Registry System: 2-Chloro-2',4'-dihydroxyacetophenone(25015-92-3)

Safety Data

• Hazardous Substances Data: 25015-92-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-2',4'-dihydroxyacetophenone is a chemical compound with the molecular formula C8H7ClO3. It is a chlorinated derivative of hydroxyacetophenone, characterized by having a chlorine atom and two hydroxy groups substituting the acetophenone structure. It is generally used for various organic syntheses. 2-Chloro-2',4'-dihydroxyacetophenone is aromatic, falling under the acetophenones family, and can be typically used in various research and experimental endeavors. Details such as its physical properties, stability, toxicity, and potential environmental impact among others will depend on additional studies.

InChI:InChI=1/C8H7ClO3/c9-4-8(12)6-2-1-5(10)3-7(6)11/h1-3,10-11H,4H2

Upstream product

• 79-07-2 Chloroacetamide 
• 108-46-3 recorcinol 
• 44169-77-9 2-chloro-acetimidoyl chloride 
• 79-04-9 chloroacetyl chloride 
• 79-11-8 chloroacetic acid 
• 107-14-2 chloroacetonitrile 
• 755722-84-0 imine 

Downstream Products

• 5786-54-9 (Z)-6-hydroxy-2-(4-hydroxybenzylidene)benzofuran-3(2H)-one 
• 61429-80-9 (2Z)-6-hydroxy-2-[(3-hydroxyphenyl)methylene]benzofuran-3-one 

Relevant articles and documents

Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents

A series of 4-dimethylamine flavonoid derivatives 5a-5r were designed, synthesized and evaluated as potential multi-functional anti-Alzheimer agents. The results showed that most of the synthesized compounds exhibited high acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity at the micromolar range (IC50, 1.83-33.20 μM for AChE and 0.82-11.45 μM for BChE). A Lineweaver-Burk plot indicated a mixed-type inhibition for compound 5j with AChE, and molecular modeling study showed that 5j targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Besides, the derivatives showed potent self-induced Aβ aggregation inhibitory activity at 20 μM with percentage from 25% to 48%. In addition, some compounds (5j-5q) showed potent oxygen radical absorbance capacity (ORAC) ranging from 1.5- to 2.6-fold of the Trolox value. These compounds should be further investigated as multi-potent agents for the treatment of Alzheimer's disease.

Design and biological evaluation of novel imidazolyl flavonoids as potent and selective protein tyrosine phosphatase inhibitors

Background: Protein tyrosine phosphatases 1B are considered to be a desirable vali-dated target for therapeutic development of type II diabetes and obesity. Methods: A new series of imidazolyl flavonoids as potential protein tyrosine phosphatase inhibi-to

Identification of novel imidazole flavonoids as potent and selective inhibitors of protein tyrosine phosphatase

A series of imidazole flavonoids as new type of protein tyrosine phosphatase inhibitors were synthesized and characterized. Most of them gave potent protein phosphatase 1B (PTP1B) inhibitory activities. Especially, compound 11a could effectively inhibit P