302554-35-4

Upstream product

• 40219-06-5 benzylidenecyanothioacetamide 
• 302554-25-2 2-(2-cyano-ethylsulfanyl)-4-phenyl-6,7-dihydro-5H-[1]pyrindine-3-carbonitrile 
• 68029-52-7 (E)-2-cyano-3-phenylprop-2-enethioamide 
• 120-92-3 cyclopentanone 
• 83236-48-0 4-phenyl-2-thioxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitrile 
• 1921-90-0 2-benzylidenecyclopentanone 
• 302554-31-0 2-(3-cyano-4-phenyl-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl)-acetamide 

Downstream Products

• 302554-59-2 7-(2-oxo-2-phenyl-ethyl)-4-phenyl-2,3-dihydro-1H,7H-9-thia-5,6,7,10-tetraaza-cyclopenta[b]fluoren-8-one 
• 723745-57-1 6-(4-methoxy-phenyl)-4-phenyl-2,3,6,7-tetrahydro-1H,5H-9-thia-5,7,10-triaza-cyclopenta[b]fluoren-8-one 

Relevant academic research and scientific papers

Novel multicomponent synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives

[Figure not available: see fulltext.] The multicomponent condensation of malononitrile, hydrogen sulfide, aldehydes, 1-(cyclopent-1-en-1-yl)pyrrolidine, and alkylating agents leads to the formation of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives. The structure of a number of heterocycles obtained on their basis was studied by X-ray structural analysis.

Synthesis, reactions and antimicrobial activity of new cyclopenta[e]thieno-[2,3-b]pyridines and related heterocyclic systems

Reaction of the arylidene cyanothioacetamides la, b with cyclopentanone was proved to give a mixture of 4-aryl-3-cyanocyclopenta[b]pyridine-2(1H)-thiones 2a, b and the corresponding 7-arylidene derivatives 3a, b. Compounds 2a, b were reacted with ethyl chloroacetate or chloroacetamide to give the promising S-substituted thiopyridines 6a-d. On treatment of the latter compounds with sodium ethoxide in boiling ethanol, they underwent intramolecular Thorpe-Ziegler cyclization to yield the corresponding 3-amino-4-aryl-2-functionalized-cyclopenta[e]thieno[2,3-b]pyridines (7a-d). Most of these thienopyridines were reacted with a variety of reagents to produce other new cyclopentathienopyridines as well as numerous of their condensed heterocyclic derivatives. Some of the compounds synthesized were tested in vitro for their antibacterial and antifungal activity.