302575-69-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(3,4,5-TRIMETHOXY-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID is used as a pharmaceutical candidate for its anti-inflammatory, anti-bacterial, and anti-malarial activities. Its potential as an antioxidant also makes it a promising candidate for the development of new drugs and treatments.
Used in Medicinal Chemistry Research:
2-(3,4,5-TRIMETHOXY-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID is utilized as a subject of study in medicinal chemistry research to explore its therapeutic potential and to develop new pharmaceutical drugs and treatments based on its unique structure and molecular properties.

Upstream product

• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 91-56-5 indole-2,3-dione 

Relevant academic research and scientific papers

Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation

The colchicine binding site of tubulin is a promising target for discovering novel antitumor agents which exert the antiangiogenic effect and are not susceptible to multidrug resistance. For identifying novel tubulin inhibitors, structure-based virtual screening was applied to identify hit 9 which displayed moderate tubulin polymerization inhibition and broad-spectrum in vitro antitumor activity. Structural optimization was performed, and biological assay revealed analog E27 displayed the best antitumor activity with IC50 values ranging from 7.81 μM to 10.36 μM, and improved tubulin polymerization inhibitory activity (IC50 = 16.1 μM). It significantly inhibited cancer cell migration and invasion, induced cell apoptosis and arrested the cell cycle at G2/M phase. Moreover, the apoptotic effect of E27 is related to the increased ROS level, the decrease of MMP, and the abnormal expression of apoptosis-related proteins. Taken together, these results suggested E27 was a promising lead compound for discovering novel tubulin-targeted antitumor agents.

NO donor type quinoline derivative as well as preparation method and application thereof

The invention belongs to the field of biological medicines, and discloses an NO donor type quinoline derivative shown as a formula I. In the formula I, R1 and R2 are respectively and independently selected from H, F, 3,4,5-trialkoxyphenyl, 3,4,5-trialkoxy