302588-39-2Relevant academic research and scientific papers
Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNAse H activity
Wang,Verbeure,Luyten,Froeyen,Hendrix,Rosemeyer,Seela,Van Aerschot,Herdewijn
, p. 785 - 788 (2001)
Cyclohexene nucleic acids (CeNA) were synthesized using classical phosporamidite chemistry. Incorporation of a cyclohexene nucleo-side in a DNA chain leads to an increase in stability of the DNA/RNA duplex. CeNA is stable against degradation in serum. A C
Synthesis of enantiomeric-pure cyclohexenyl nucleoside building blocks for oligonucleotide synthesis
Gu, Ping,Griebel, Carsten,Van Aerschot, Arthur,Rozenski, Jef,Busson, Roger,Gais, Hans-Joachim,Herdewijn, Piet
, p. 2111 - 2123 (2007/10/03)
Lipases were used for the resolution of (±) (4aR, 7R, 8aS)-2-phenyl-4a,7,8,8a-tetrahydro-4H-1,3-benzodioxine. This separation was carried out on preparative scale and used for the synthesis of eight phosphoramidites of cyclohexenyl nucleosides (D- and L-series).
Cyclohexene nucleic acids (CeNA): Serum stable oligonucleotides that activate RNase H and increase duplex stability with complementary RNA
Wang, Jing,Verbeure, Birgit,Luyten, Ingrid,Lescrinier, Eveline,Froeyen, Matthias,Hendrix, Chris,Rosemeyer, Helmut,Seela, Frank,Van Aerschot, Arthur,Herdewijn, Piet
, p. 8595 - 8602 (2007/10/03)
The replacement of the furanose moiety of DNA by a cyclohexene ring gives a new nucleic acid structure: cyclohexene nucleic acids or CeNA. CeNAs can be obtained by the classical phosphoramidite chemisty starting from protected cyclohexenyl nucleoside buil
