30264-48-3Relevant academic research and scientific papers
A reversible fluorescent probe for directly monitoring protein-small molecules interaction utilizing vibration-induced emission
Wang, Na,Xin, Chenqi,Li, Zheng,Zhang, Gaobin,Bai, Lei,Gong, Qiuyu,Xu, Chenchen,Han, Xu,Yu, Changmin,Li, Lin,Huang, Wei
, p. 425 - 432 (2019)
The interactions between proteins and small molecules play an important role in the regulation of various cellular processes and modern drug discovery. Herein, we have developed a novel strategy for real-time monitoring the protein-ligand interaction based on vibration-induced emission (VIE) mechanism. These results demonstrated that the probe DPAC-DB could directly visualize the binding process in biotin-avidin system, which was undisturbed to other environmental stimuli, such as pH, interference species and temperature. Furthermore, the unique VIE effect caused by dramatic and reversible intramolecular vibrations enabled our strategy possible to build up the bio-logic gate. This method to efficiently control the emission of VIE-based probe through the reversible noncovalent protein-small molecules interactions opens new avenues for the development of potent protein pharmaceuticals and small molecule drugs.
Phenazine-based colorimetric and fluorometric probes for rapid recognizing of Hg2+ with high sensitivity and selectivity
Zhou, Haitao,Sun, Lu,Chen, Wei,Tian, Guojian,Chen, Yi,Li, Yiru,Su, Jianhua
, p. 2300 - 2305 (2016)
Two colorimetric and fluorometric probes, namely 2a and 2b, based on N,N′-disubstituted-dihydrophenazine analogues for rapid detection of Hg2+ with high sensitivity and selectivity were designed and synthesized by Heck coupling reaction. The responsive optical properties of the two sensors were investigated by UV-vis absorption and fluorescence spectroscopy in THF solution and 2a-b were found to be exclusively responsive to Hg2+ rapidly. Remarkably, the detection limits of 2a-b for Hg2+ were determined to be 4.8 and 2.6 nM, respectively. Moreover, the AIE and pH sensing properties of 2a-b were investigated.
Mitochondrion-targeting chemiluminescent ternary supramolecular assembly for: In situ photodynamic therapy
Chen, Lei,Chen, Yong,Li, Jingjing,Liu, Yu,Zhang, Yi,Zhou, Weilei
, p. 8857 - 8860 (2020)
The development of smart supramolecular self-assemblies for photodynamic therapy (PDT) and organelle-targeting cell imaging has become a hot topic of research due to their rapid and intelligent responses. Herein, we report a novel ternary supramolecular a
Crown ether compound, preparation method of crown ether compound, and application of crown ether compound in ion recognition
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Paragraph 0045-0050, (2020/02/19)
The invention discloses a crown ether compound having a general formula as shown in formula I or an isomer thereof: In the formula I, n is an integer of 2-5. After extensive and in-depth research, thecrown ether compound with a novel structure is designed and synthesized, the crown ether compound can form complexes with potassium, sodium, and ammonium salts and can specifically recognize sodium ions. Therefore, the types of crown ethers are enriched, the application fields of the crown ethers are broadened, and the crown ether compound can be used in technical fields such as ion recognition and drug carriers.
White-Fluorescent Dual-Emission Mechanosensitive Membrane Probes that Function by Bending Rather than Twisting
Humeniuk, Heorhii V.,Rosspeintner, Arnulf,Licari, Giuseppe,Kilin, Vasyl,Bonacina, Luigi,Vauthey, Eric,Sakai, Naomi,Matile, Stefan
supporting information, p. 10559 - 10563 (2018/08/17)
Bent N,N′-diphenyl-dihydrodibenzo[a,c]phenazine amphiphiles are introduced as mechanosensitive membrane probes that operate by an unprecedented mechanism, namely, unbending in the excited state as opposed to the previously reported untwisting in the ground and twisting in the excited state. Their dual emission from bent or “closed” and planarized or “open” excited states is shown to discriminate between micelles in water and monomers in solid-ordered (So), liquid-disordered (Ld) and bulk membranes. The dual-emission spectra cover enough of the visible range to produce vesicles that emit white light with ratiometrically encoded information. Strategies to improve the bent mechanophores with expanded π systems and auxochromes are reported, and compatibility with imaging of membrane domains in giant unilamellar vesicles by two-photon excitation fluorescence (TPEF) microscopy is demonstrated.
Phenanthrylenediamine derivative
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, (2008/06/13)
In accordance with the present invention, there is provided a phenanthrylenediamine derivative represented by the general formula (1). The derivative is excellent in the electric charge transferring capability, the compatibility with a binding resin and t
